HCSGD entry for PER2
1. General information
| Official gene symbol | PER2 |
|---|---|
| Entrez ID | 8864 |
| Gene full name | period circadian clock 2 |
| Other gene symbols | FASPS FASPS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA ISS | biological_process |
| GO:0000988 | Protein binding transcription factor activity | IEA | molecular_function |
| GO:0000989 | Transcription factor binding transcription factor activity | ISS | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007623 | Circadian rhythm | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3081839786 | 0.2739297405 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.1211088353 |
| GSE13712_SHEAR | Up | 0.0362451903 |
| GSE13712_STATIC | Up | 0.4210074755 |
| GSE19018 | Down | -0.5242525411 |
| GSE19899_A1 | Up | 0.1668502217 |
| GSE19899_A2 | Down | -0.1325302164 |
| PubMed_21979375_A1 | Up | 0.0013611007 |
| PubMed_21979375_A2 | Down | -0.5380597139 |
| GSE35957 | Down | -0.1762280003 |
| GSE36640 | Up | 0.1245661675 |
| GSE54402 | Down | -0.1403299374 |
| GSE9593 | Up | 0.1989024264 |
| GSE43922 | Up | 0.0519414996 |
| GSE24585 | Up | 0.2788218083 |
| GSE37065 | Up | 0.0320525742 |
| GSE28863_A1 | Up | 0.5315642387 |
| GSE28863_A2 | Up | 0.2750847526 |
| GSE28863_A3 | Up | 0.0960142569 |
| GSE28863_A4 | Down | -0.0655637775 |
| GSE48662 | Up | 0.1102467260 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT030473 | qRT-PCR;Microarray | Functional MTI (Weak) | 19748357 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26961881 | Mouse embryonic fibroblasts prepared from animals deficient in negative circadian clock regulators, Period2 (Per2) or Cryptochrome1/2 (Cry1/2), were prone to transformation induced by co-expression of H-ras(V12) and SV40 large T antigen (SV40LT) |
| 26961881 | In Per2 mutant and Cry1/2-null cells, the introduction of oncogenes induced expression of ATF4, a potent repressor of cell senescence-associated proteins p16INK4a and p19ARF |
| 26361874 | The deacetylase Sirtuin 1 (SIRT1) regulates the timing of the clock through acetylation of BMAL1 and PER2 and controls the clock-dependent functions, which can also be affected by environmental stressors |
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