HCSGD entry for NR1I2

1. General information

Official gene symbolNR1I2
Entrez ID8856
Gene full namenuclear receptor subfamily 1, group I, member 2
Other gene symbolsBXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0004887Thyroid hormone receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006805Xenobiotic metabolic processIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008202Steroid metabolic processTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0030522Intracellular receptor signaling pathwayIDAbiological_process
GO:0042738Exogenous drug catabolic processIDAbiological_process
GO:0042908Xenobiotic transportIDAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046618Drug exportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87661471830.78768802480.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0250211845
GSE13712_SHEARDown-0.0372726992
GSE13712_STATICUp0.0170232026
GSE19018Up0.0379990053
GSE19899_A1Down-0.0771189971
GSE19899_A2Up0.0875517801
PubMed_21979375_A1Down-0.0058426927
PubMed_21979375_A2Down-0.0965921605
GSE35957Up0.0626073542
GSE36640Down-0.0013276434
GSE54402Down-0.0931813338
GSE9593Down-0.0028429292
GSE43922Up0.0938382979
GSE24585Down-0.0421406342
GSE37065Down-0.0257134578
GSE28863_A1Down-0.0320162132
GSE28863_A2Up0.0785196434
GSE28863_A3Up0.1535600910
GSE28863_A4Up0.0751024748
GSE48662Down-0.0200505625

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Vitamin EDB00163 NUTR00061 | EXPT03227
ErlotinibDB00530 APRD00951
RifampicinDB01045 APRD00207 | EXPT02777
RifaximinDB01220 APRD01218
DocetaxelDB01248 APRD00932
DehydroepiandrosteroneDB01708 EXPT00519 | DB06593
HyperforinDB01892 EXPT01804
SR12813DB04466 EXPT02953
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDEDB07080 -
RilpivirineDB08864 DB08592 | DB05083

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7a-5pMIMAT0000062MIRT002079Luciferase reporter assayNon-Functional MTI17890240
hsa-miR-148a-3pMIMAT0000243MIRT003998Luciferase reporter assay//qRT-PCRFunctional MTI18268015
hsa-miR-615-3pMIMAT0003283MIRT040092CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051226CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-148a-3pMIMAT00002431hsa-miR-148a{Western blot}{Western blot}{overexpression by miRNA precursor transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}18268015
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.