HCSGD entry for PROM1
1. General information
| Official gene symbol | PROM1 |
|---|---|
| Entrez ID | 8842 |
| Gene full name | prominin 1 |
| Other gene symbols | AC133 CD133 CORD12 MCDR2 PROML1 RP41 STGD4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001750 | Photoreceptor outer segment | ISS | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IEA | cellular_component |
| GO:0005903 | Brush border | IEA | cellular_component |
| GO:0009986 | Cell surface | IDA IEA | cellular_component |
| GO:0010842 | Retina layer formation | ISS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0031528 | Microvillus membrane | IEA | cellular_component |
| GO:0032420 | Stereocilium | IEA | cellular_component |
| GO:0042622 | Photoreceptor outer segment membrane | IDA | cellular_component |
| GO:0042805 | Actinin binding | IDA | molecular_function |
| GO:0045296 | Cadherin binding | IPI | molecular_function |
| GO:0045494 | Photoreceptor cell maintenance | IMP | biological_process |
| GO:0060042 | Retina morphogenesis in camera-type eye | IMP | biological_process |
| GO:0060219 | Camera-type eye photoreceptor cell differentiation | IMP ISS | biological_process |
| GO:0072112 | Glomerular visceral epithelial cell differentiation | IMP | biological_process |
| GO:0072139 | Glomerular parietal epithelial cell differentiation | IMP | biological_process |
| GO:2000768 | Positive regulation of nephron tubule epithelial cell differentiation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5703393982 | 0.4347724745 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2066960247 |
| GSE13712_SHEAR | Down | -0.0654352177 |
| GSE13712_STATIC | Up | 0.1144887486 |
| GSE19018 | Down | -0.3375614649 |
| GSE19899_A1 | Up | 0.0260459684 |
| GSE19899_A2 | Up | 0.3938854425 |
| PubMed_21979375_A1 | Up | 0.0853341890 |
| PubMed_21979375_A2 | Down | -0.0328946089 |
| GSE35957 | Up | 0.0923734903 |
| GSE36640 | Up | 0.1992471788 |
| GSE54402 | Up | 0.1743127819 |
| GSE9593 | Up | 0.0949540748 |
| GSE43922 | Up | 0.0216926083 |
| GSE24585 | Down | -1.3257288795 |
| GSE37065 | Down | -0.0423809892 |
| GSE28863_A1 | Up | 0.0007968684 |
| GSE28863_A2 | Up | 0.0975457024 |
| GSE28863_A3 | Up | 0.0822605928 |
| GSE28863_A4 | Up | 0.0468944639 |
| GSE48662 | Down | -0.0341206581 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-142-3p | MIMAT0000434 | MIRT021645 | Reporter assay | Functional MTI | 21394831 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26097880 | We recently developed CAR T cells targeting the prototypic cancer stem cell marker AC133 and showed that these CAR T cells killed AC133+ glioblastoma stem cells (GBM-SCs) in vitro and inhibited the growth of brain tumors initiated from GBM-SCs in xenograft mouse models in vivo |
| 25426558 | The AC133 epitope of CD133 is a cancer stem cell (CSC) marker for many tumor entities, including the highly malignant glioblastoma multiforme (GBM) |
| 25426558 | We have developed an AC133-specific chimeric antigen receptor (CAR) and show that AC133-CAR T cells kill AC133+ GBM stem cells (GBM-SCs) both in vitro and in an orthotopic tumor model in vivo |
| 25239491 | Successful CD133+ mobilizers expressed fewer senescence-associated genes compared with poor mobilizers |
| 25239491 | However, poor mobilization efficiency combined with high CD133+ senescence suggests futility in this approach |
| 22719071 | In this study, we used quantitative real-time-PCR to define miRNA expression patterns in various stem/progenitor cell populations in prostate cancer, including CD44+, CD133+, integrin alpha2beta1+, and side population cells |
| 20424141 | Results of flow cytometry showed that EPCs after 7 days of culture expressed both stem cell markers CD34 and CD133 and endothelial cell markers VEGFR-2 (flk-1) and VE-cadherin |
| 17545049 | The expressions of CD29, CD44, and CD34 were observed in ASCs by flow cytometry while HLA-DR or CD133 expression was not detected |
| 16698211 | CD34+/CD133 senescence and in vivo application |
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