HCSGD entry for CFLAR

1. General information

Official gene symbolCFLAR
Entrez ID8837
Gene full nameCASP8 and FADD-like apoptosis regulator
Other gene symbolsCASH CASP8AP1 CLARP Casper FLAME FLAME-1 FLAME1 FLIP I-FLICE MRIT c-FLIP c-FLIPL c-FLIPR c-FLIPS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002020Protease bindingIPImolecular_function
GO:0004197Cysteine-type endopeptidase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006915Apoptotic processIMP TASbiological_process
GO:0007519Skeletal muscle tissue developmentISSbiological_process
GO:0008047Enzyme activator activityIDAmolecular_function
GO:0014732Skeletal muscle atrophyISSbiological_process
GO:0014842Regulation of satellite cell proliferationISSbiological_process
GO:0014866Skeletal myofibril assemblyISSbiological_process
GO:0016032Viral processIEAbiological_process
GO:0031264Death-inducing signaling complexIDAcellular_component
GO:0031265CD95 death-inducing signaling complexIEAcellular_component
GO:0042981Regulation of apoptotic processIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043403Skeletal muscle tissue regenerationISSbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityISSbiological_process
GO:0060544Regulation of necroptotic processIDAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:0097342RipoptosomeIDAcellular_component
GO:1901740Negative regulation of myoblast fusionISSbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIMPbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIDA IMPbiological_process
GO:2001239Regulation of extrinsic apoptotic signaling pathway in absence of ligandTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00983729340.77889757610.25337788651.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1160252040
GSE13712_SHEARUp0.3142926793
GSE13712_STATICUp0.0486334450
GSE19018Down-0.0569900692
GSE19899_A1Up0.0281323085
GSE19899_A2Up0.4980773740
PubMed_21979375_A1Up0.1388107384
PubMed_21979375_A2Down-0.1562538261
GSE35957Up0.6985920649
GSE36640Up1.0691237328
GSE54402Up0.4221740027
GSE9593Up0.8757612738
GSE43922Down-0.2144247398
GSE24585Up1.1185514249
GSE37065Up0.4675778746
GSE28863_A1Up0.9749962527
GSE28863_A2Up0.4285493948
GSE28863_A3Down-0.3387774883
GSE28863_A4Down-0.5018998825
GSE48662Up0.2376599137

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-346MIMAT0000773MIRT004228MicroarrayFunctional MTI (Weak)16822819
hsa-miR-7-5pMIMAT0000252MIRT025744MicroarrayFunctional MTI (Weak)19073608
hsa-miR-26a-5pMIMAT0000082MIRT050158CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-512-3pMIMAT0002823NAhsa-miR-512-3p20372864
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24589226Senescent cell-induced MYC silenced its target gene CFLAR, encoding the apoptosis inhibitor FLIPL , thus leading to the acquisition of TRAIL sensitivity
24589226Altogether, our results reveal that senescent cell-secreted factors exert a TRAIL-sensitizing effect on pretransformed cells by modulating the expression of MYC and CFLAR
22829758These include COL4A3, CFLAR, GULP1, PDCD1, CASP10, PAX3, BOK, HSPD1, PITX2, and PML
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