HCSGD entry for SOCS2
1. General information
Official gene symbol | SOCS2 |
---|---|
Entrez ID | 8835 |
Gene full name | suppressor of cytokine signaling 2 |
Other gene symbols | CIS2 Cish2 SOCS-2 SSI-2 SSI2 STATI2 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001558 | Regulation of cell growth | IEA NAS | biological_process |
GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
GO:0005131 | Growth hormone receptor binding | NAS | molecular_function |
GO:0005159 | Insulin-like growth factor receptor binding | IEA IPI | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005737 | Cytoplasm | IEA NAS | cellular_component |
GO:0005829 | Cytosol | TAS | cellular_component |
GO:0007259 | JAK-STAT cascade | TAS | biological_process |
GO:0007568 | Aging | IEA | biological_process |
GO:0008269 | JAK pathway signal transduction adaptor activity | IEA | molecular_function |
GO:0009966 | Regulation of signal transduction | NAS | biological_process |
GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
GO:0016567 | Protein ubiquitination | IEA | biological_process |
GO:0032355 | Response to estradiol | IDA | biological_process |
GO:0032870 | Cellular response to hormone stimulus | IDA | biological_process |
GO:0035556 | Intracellular signal transduction | IEA | biological_process |
GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
GO:0043434 | Response to peptide hormone | IEA | biological_process |
GO:0046426 | Negative regulation of JAK-STAT cascade | IEA | biological_process |
GO:0060396 | Growth hormone receptor signaling pathway | IDA | biological_process |
GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.7645710953 | 0.0001292466 | 0.9999902473 | 0.0202052326 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.0106536535 |
GSE13712_SHEAR | Up | 0.3522515372 |
GSE13712_STATIC | Up | 0.3680215142 |
GSE19018 | Up | 0.9996409097 |
GSE19899_A1 | Down | -3.1683503412 |
GSE19899_A2 | Down | -1.5050672739 |
PubMed_21979375_A1 | Down | -1.6900046785 |
PubMed_21979375_A2 | Down | -2.6153475243 |
GSE35957 | Down | -0.6013530896 |
GSE36640 | Down | -2.5908733860 |
GSE54402 | Down | -0.6807080615 |
GSE9593 | Down | -0.8400905476 |
GSE43922 | Down | -1.5566591212 |
GSE24585 | Down | -0.1599826853 |
GSE37065 | Up | 0.1967232630 |
GSE28863_A1 | Down | -0.5550047287 |
GSE28863_A2 | Down | -1.2886428930 |
GSE28863_A3 | Down | -0.3760124080 |
GSE28863_A4 | Down | -0.1672984784 |
GSE48662 | Down | -0.4702307083 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-194-5p | MIMAT0000460 | MIRT005896 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20979124 |
hsa-miR-7-5p | MIMAT0000252 | MIRT025940 | Microarray | Functional MTI (Weak) | 17612493 |
hsa-miR-16-5p | MIMAT0000069 | MIRT051211 | CLASH | Functional MTI (Weak) | 23622248 |
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