HCSGD entry for SOCS2


1. General information

Official gene symbolSOCS2
Entrez ID8835
Gene full namesuppressor of cytokine signaling 2
Other gene symbolsCIS2 Cish2 SOCS-2 SSI-2 SSI2 STATI2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001558Regulation of cell growthIEA NASbiological_process
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0005131Growth hormone receptor bindingNASmolecular_function
GO:0005159Insulin-like growth factor receptor bindingIEA IPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEA NAScellular_component
GO:0005829CytosolTAScellular_component
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008269JAK pathway signal transduction adaptor activityIEAmolecular_function
GO:0009966Regulation of signal transductionNASbiological_process
GO:0009967Positive regulation of signal transductionTASbiological_process
GO:0016567Protein ubiquitinationIEAbiological_process
GO:0032355Response to estradiolIDAbiological_process
GO:0032870Cellular response to hormone stimulusIDAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0046426Negative regulation of JAK-STAT cascadeIEAbiological_process
GO:0060396Growth hormone receptor signaling pathwayIDAbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.76457109530.00012924660.99999024730.0202052326

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0106536535
GSE13712_SHEARUp0.3522515372
GSE13712_STATICUp0.3680215142
GSE19018Up0.9996409097
GSE19899_A1Down-3.1683503412
GSE19899_A2Down-1.5050672739
PubMed_21979375_A1Down-1.6900046785
PubMed_21979375_A2Down-2.6153475243
GSE35957Down-0.6013530896
GSE36640Down-2.5908733860
GSE54402Down-0.6807080615
GSE9593Down-0.8400905476
GSE43922Down-1.5566591212
GSE24585Down-0.1599826853
GSE37065Up0.1967232630
GSE28863_A1Down-0.5550047287
GSE28863_A2Down-1.2886428930
GSE28863_A3Down-0.3760124080
GSE28863_A4Down-0.1672984784
GSE48662Down-0.4702307083

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-194-5pMIMAT0000460MIRT005896Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20979124
hsa-miR-7-5pMIMAT0000252MIRT025940MicroarrayFunctional MTI (Weak)17612493
hsa-miR-16-5pMIMAT0000069MIRT051211CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.