HCSGD entry for SYNGAP1

1. General information

Official gene symbolSYNGAP1
Entrez ID8831
Gene full namesynaptic Ras GTPase activating protein 1
Other gene symbolsMRD5 RASA1 RASA5 SYNGAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005096GTPase activator activityIEAmolecular_function
GO:0005097Rab GTPase activator activityIEAmolecular_function
GO:0005099Ras GTPase activator activityIBAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0007165Signal transductionIEAbiological_process
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0007389Pattern specification processIEAbiological_process
GO:0008542Visual learningIEAbiological_process
GO:0016358Dendrite developmentIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0031235Intrinsic component of the cytoplasmic side of the plasma membraneIBAcellular_component
GO:0032320Positive regulation of Ras GTPase activityIBAbiological_process
GO:0043113Receptor clusteringIEAbiological_process
GO:0043198Dendritic shaftIEAcellular_component
GO:0043408Regulation of MAPK cascadeIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0046580Negative regulation of Ras protein signal transductionIBA ISSbiological_process
GO:0048167Regulation of synaptic plasticityISSbiological_process
GO:0048169Regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0050771Negative regulation of axonogenesisIEAbiological_process
GO:0050803Regulation of synapse structure and activityIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65996760380.83457454120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0494985268
GSE13712_SHEARDown-0.3979616615
GSE13712_STATICDown-0.1855474954
GSE19018Up0.1605596277
GSE19899_A1Up0.0922280430
GSE19899_A2Up0.3005813757
PubMed_21979375_A1Up0.1614617566
PubMed_21979375_A2Down-0.1497576366
GSE35957Down-0.0723286115
GSE36640Up0.2729236492
GSE54402Up0.0983860102
GSE9593Down-0.0504712194
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1164426333

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92b-3pMIMAT0003218MIRT040627CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-145-5pMIMAT0000437NAhsa-miR-14519915607
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.