HCSGD entry for NRP1

1. General information

Official gene symbolNRP1
Entrez ID8829
Gene full nameneuropilin 1
Other gene symbolsBDCA4 CD304 NP1 NRP VEGF165R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001569Patterning of blood vesselsISSbiological_process
GO:0001764Neuron migrationISSbiological_process
GO:0001938Positive regulation of endothelial cell proliferationTASbiological_process
GO:0002042Cell migration involved in sprouting angiogenesisISSbiological_process
GO:0002116Semaphorin receptor complexNAScellular_component
GO:0005021Vascular endothelial growth factor-activated receptor activityIEA ISS NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005883NeurofilamentIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006468Protein phosphorylationISS NAS TASbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007411Axon guidanceIEA NAS TASbiological_process
GO:0007413Axonal fasciculationIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008152Metabolic processISS NAS TASbiological_process
GO:0008201Heparin bindingIEAmolecular_function
GO:0009611Response to woundingIEAbiological_process
GO:0009887Organ morphogenesisIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010595Positive regulation of endothelial cell migrationTASbiological_process
GO:0014911Positive regulation of smooth muscle cell migrationTASbiological_process
GO:0015026Coreceptor activityTASmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016310PhosphorylationISS NAS TASbiological_process
GO:0016358Dendrite developmentIEAbiological_process
GO:0017154Semaphorin receptor activityIEA NASmolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationISS NAS TASbiological_process
GO:0019838Growth factor bindingIEA IPI TASmolecular_function
GO:0019955Cytokine bindingNASmolecular_function
GO:0021636Trigeminal nerve morphogenesisIEAbiological_process
GO:0021675Nerve developmentISSbiological_process
GO:0030424AxonISScellular_component
GO:0030426Growth coneIEAcellular_component
GO:0031290Retinal ganglion cell axon guidanceISSbiological_process
GO:0031410Cytoplasmic vesicleTAScellular_component
GO:0035729Cellular response to hepatocyte growth factor stimulusIMPbiological_process
GO:0035767Endothelial cell chemotaxisIEA IMPbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043235Receptor complexTAScellular_component
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048008Platelet-derived growth factor receptor signaling pathwayIMPbiological_process
GO:0048010Vascular endothelial growth factor receptor signaling pathwayIEA IMP TASbiological_process
GO:0048012Hepatocyte growth factor receptor signaling pathwayIMPbiological_process
GO:0048842Positive regulation of axon extension involved in axon guidanceISSbiological_process
GO:0048843Negative regulation of axon extension involved in axon guidanceIEAbiological_process
GO:0048846Axon extension involved in axon guidanceISSbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIMPbiological_process
GO:0050918Positive chemotaxisISSbiological_process
GO:0060301Positive regulation of cytokine activityTASbiological_process
GO:0060385Axonogenesis involved in innervationISSbiological_process
GO:0060627Regulation of vesicle-mediated transportTASbiological_process
GO:0060666Dichotomous subdivision of terminal units involved in salivary gland branchingIEAbiological_process
GO:0061549Sympathetic ganglion developmentISSbiological_process
GO:0071526Semaphorin-plexin signaling pathwayNASbiological_process
GO:0071679Commissural neuron axon guidanceISSbiological_process
GO:0090259Regulation of retinal ganglion cell axon guidanceISSbiological_process
GO:0097102Endothelial tip cell fate specificationISSbiological_process
GO:0097490Sympathetic neuron projection extensionISSbiological_process
GO:0097491Sympathetic neuron projection guidanceISSbiological_process
GO:1902285Semaphorin-plexin signaling pathway involved in neuron projection guidanceISSbiological_process
GO:1902336Positive regulation of retinal ganglion cell axon guidanceISSbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35828533110.06816801410.99999024730.4928853337

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7898505820
GSE13712_SHEARDown-0.1340474224
GSE13712_STATICDown-0.1621181467
GSE19018Down-0.1272255049
GSE19899_A1Up0.2161221656
GSE19899_A2Down-0.2315960303
PubMed_21979375_A1Down-0.9654234939
PubMed_21979375_A2Up0.0003939219
GSE35957Down-0.2016171975
GSE36640Down-1.2259593100
GSE54402Up0.3991452441
GSE9593Up0.4210499740
GSE43922Down-0.0330199596
GSE24585Down-0.8226319834
GSE37065Down-0.1250549479
GSE28863_A1Up0.7195389360
GSE28863_A2Up0.0954196639
GSE28863_A3Down-0.3561196010
GSE28863_A4Up0.0308192524
GSE48662Down-0.6000391699

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PaliferminDB00039 BTD00042 | BIOD00042
PegaptanibDB04895 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT001352pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-335-5pMIMAT0000765MIRT017659MicroarrayFunctional MTI (Weak)18185580
hsa-miR-186-5pMIMAT0000456MIRT021183SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT022578MicroarrayFunctional MTI (Weak)18668037
hsa-miR-181a-5pMIMAT0000256MIRT025124MicroarrayFunctional MTI (Weak)17612493
hsa-miR-181a-5pMIMAT0000256MIRT025124SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031601ProteomicsFunctional MTI (Weak)18668040
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.