HCSGD entry for NRP2
1. General information
| Official gene symbol | NRP2 |
|---|---|
| Entrez ID | 8828 |
| Gene full name | neuropilin 2 |
| Other gene symbols | NP2 NPN2 PRO2714 VEGF165R2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA NAS | biological_process |
| GO:0001755 | Neural crest cell migration | IEA | biological_process |
| GO:0001938 | Positive regulation of endothelial cell proliferation | TAS | biological_process |
| GO:0002116 | Semaphorin receptor complex | NAS | cellular_component |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005021 | Vascular endothelial growth factor-activated receptor activity | IEA NAS | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | NAS TAS | biological_process |
| GO:0007155 | Cell adhesion | IEA NAS | biological_process |
| GO:0007411 | Axon guidance | IEA NAS TAS | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0008152 | Metabolic process | NAS TAS | biological_process |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0010595 | Positive regulation of endothelial cell migration | TAS | biological_process |
| GO:0016020 | Membrane | IEA TAS | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0016310 | Phosphorylation | NAS TAS | biological_process |
| GO:0017154 | Semaphorin receptor activity | IEA NAS | molecular_function |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | NAS TAS | biological_process |
| GO:0019838 | Growth factor binding | TAS | molecular_function |
| GO:0019955 | Cytokine binding | NAS | molecular_function |
| GO:0021675 | Nerve development | IEA ISS | biological_process |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048010 | Vascular endothelial growth factor receptor signaling pathway | TAS | biological_process |
| GO:0048846 | Axon extension involved in axon guidance | IEA ISS | biological_process |
| GO:0050919 | Negative chemotaxis | IEA | biological_process |
| GO:0061549 | Sympathetic ganglion development | IEA ISS | biological_process |
| GO:0097490 | Sympathetic neuron projection extension | IEA ISS | biological_process |
| GO:0097491 | Sympathetic neuron projection guidance | IEA ISS | biological_process |
| GO:1902285 | Semaphorin-plexin signaling pathway involved in neuron projection guidance | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5979529197 | 0.0755873333 | 0.9999902473 | 0.5192949426 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3988783156 |
| GSE13712_SHEAR | Down | -0.6082486364 |
| GSE13712_STATIC | Down | -0.3243815299 |
| GSE19018 | Down | -0.3741720869 |
| GSE19899_A1 | Up | 0.1009734507 |
| GSE19899_A2 | Down | -0.4121895868 |
| PubMed_21979375_A1 | Up | 0.1342954852 |
| PubMed_21979375_A2 | Up | 0.3999079547 |
| GSE35957 | Down | -0.0160739831 |
| GSE36640 | Down | -0.4003811476 |
| GSE54402 | Down | -0.1020601336 |
| GSE9593 | Down | -0.1920390456 |
| GSE43922 | Up | 0.8972290950 |
| GSE24585 | Down | -0.1917479902 |
| GSE37065 | Up | 0.4891456967 |
| GSE28863_A1 | Up | 0.2701503676 |
| GSE28863_A2 | Up | 0.0827385599 |
| GSE28863_A3 | Down | -0.2576130971 |
| GSE28863_A4 | Down | -0.2699239096 |
| GSE48662 | Down | -0.1355127118 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017537 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT019236 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT025587 | Reporter assay | Non-Functional MTI | 21642433 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17495774 | Genes with biologic significance regulated during degeneration involved cell senescence, low cell division rates, hypoxia-related genes, heat-shock protein 70 interacting protein, neuropilin 2, and interleukin-23p19 (interleukin-12 family) |
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