HCSGD entry for INPP4B

1. General information

Official gene symbolINPP4B
Entrez ID8821
Gene full nameinositol polyphosphate-4-phosphatase, type II, 105kDa
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008289Lipid bindingIEAmolecular_function
GO:0016311DephosphorylationTASbiological_process
GO:0016316Phosphatidylinositol-3,4-bisphosphate 4-phosphatase activityIEAmolecular_function
GO:0034594Phosphatidylinositol trisphosphate phosphatase activityIEAmolecular_function
GO:0034597Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activityIEAmolecular_function
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045671Negative regulation of osteoclast differentiationIEAbiological_process
GO:0046822Regulation of nucleocytoplasmic transportIEAbiological_process
GO:0046850Regulation of bone remodelingIEAbiological_process
GO:0051896Regulation of protein kinase B signalingIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05284964100.28834945860.50257072201.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5447791422
GSE13712_SHEARDown-0.0817367233
GSE13712_STATICUp0.1276533651
GSE19018Up0.2296712457
GSE19899_A1Down-0.1337111911
GSE19899_A2Down-0.3722905024
PubMed_21979375_A1Up0.7801377812
PubMed_21979375_A2Up1.0886422844
GSE35957Up0.7932933818
GSE36640Down-0.3572093525
GSE54402Down-0.3249694783
GSE9593Up0.2529021126
GSE43922Down-0.0495349039
GSE24585Up0.5494890958
GSE37065Up0.4193862061
GSE28863_A1Down-0.8996355513
GSE28863_A2Up0.6224304967
GSE28863_A3Down-0.3281514238
GSE28863_A4Down-0.2744754080
GSE48662Up0.2573554833

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19647222We report that knocking down the expression of inositol polyphosphate 4-phosphatase type II (INPP4B) in human epithelial cells, like knockdown of PTEN, resulted in enhanced Akt activation and anchorage-independent growth and enhanced overall motility
19647222In xenograft experiments, overexpression of INPP4B resulted in reduced tumor growth
19647222INPP4B preferentially hydrolyzes phosphatidylinositol-3,4-bisphosphate (PI(3,4)P(2)) with no effect on phosphatidylinositol-3
19647222Dual knockdown of INPP4B and PTEN resulted in cellular senescence
19647222Finally, we found loss of heterozygosity (LOH) at the INPP4B locus in a majority of basal-like breast cancers, as well as in a significant fraction of ovarian cancers, which correlated with lower overall patient survival, suggesting that INPP4B is a tumor suppressor
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