HCSGD entry for BANF1
1. General information
| Official gene symbol | BANF1 |
|---|---|
| Entrez ID | 8815 |
| Gene full name | barrier to autointegration factor 1 |
| Other gene symbols | BAF BCRP1 D14S1460 NGPS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007077 | Mitotic nuclear envelope disassembly | TAS | biological_process |
| GO:0007084 | Mitotic nuclear envelope reassembly | TAS | biological_process |
| GO:0009615 | Response to virus | TAS | biological_process |
| GO:0015074 | DNA integration | IEA | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0075713 | Establishment of integrated proviral latency | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9740632499 | 0.0538337829 | 0.9999902473 | 0.4371980870 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1169098935 |
| GSE13712_SHEAR | Up | 0.0585042687 |
| GSE13712_STATIC | Down | -0.1083356253 |
| GSE19018 | Down | -0.3701852840 |
| GSE19899_A1 | Down | -0.6211388426 |
| GSE19899_A2 | Up | 0.1839312995 |
| PubMed_21979375_A1 | Down | -0.0676326892 |
| PubMed_21979375_A2 | Down | -0.0537543795 |
| GSE35957 | Down | -0.4230297719 |
| GSE36640 | Down | -0.9429549438 |
| GSE54402 | Up | 0.0601709912 |
| GSE9593 | Down | -0.3702230550 |
| GSE43922 | Down | -0.0677320253 |
| GSE24585 | Down | -0.1013053435 |
| GSE37065 | Down | -0.0675056495 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2431549203 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22297442 | Rapamycin treatment of progeria cells lowers progerin, as well as wild-type prelamin A levels, and rescues the chromatin phenotype of cultured fibroblasts, including histone methylation status and BAF and LAP2alpha distribution patterns |
| 17519288 | Barrier-to-autointegration factor (BAF) is a conserved metazoan protein that plays a critical role in retrovirus infection |
| 17519288 | To elucidate its role in uninfected cells, we first examined the localization of BAF in both mortal and immortal or cancerous human cell lines |
| 17519288 | TIG-1, WI-38 and IMR-90 cells) BAF localization depended on the age of the cell, localizing primarily in the nucleus of >90% of young proliferating cells but only 20-25% of aged senescent cells |
| 17519288 | HeLa, SiHa and HT1080 cells) BAF showed heterogeneous localization between the nucleus and cytoplasm |
| 17519288 | In S-phase-synchronized populations, the percentage of cells with predominantly nuclear BAF increased from 30% (asynchronous controls) to approximately 80% |
| 17519288 | In HeLa cells, RNAi-induced downregulation of BAF significantly increased the proportion of early S-phase cells that retained high levels of cyclin D3 and cyclin E expression and slowed progression through early S phase |
| 17519288 | BAF downregulation also caused lamin A to mislocalize away from the nuclear envelope |
| 17519288 | These results indicate that BAF is required for the integrity of the nuclear lamina and normal progression of S phase in human cells |
| 14729964 | The ubiquitous mammalian chromatin-remodeling SWI/SNF-like BAF complexes play critical roles in tumorigenesis |
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