HCSGD entry for CREG1
1. General information
| Official gene symbol | CREG1 |
|---|---|
| Entrez ID | 8804 |
| Gene full name | cellular repressor of E1A-stimulated genes 1 |
| Other gene symbols | CREG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0010181 | FMN binding | IEA | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0040008 | Regulation of growth | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0050034649 | 0.6260546446 | 0.1854230661 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4527230866 |
| GSE13712_SHEAR | Down | -0.6169037666 |
| GSE13712_STATIC | Down | -0.6717859747 |
| GSE19018 | Down | -0.2781322288 |
| GSE19899_A1 | Down | -0.4623983902 |
| GSE19899_A2 | Up | 0.5515664852 |
| PubMed_21979375_A1 | Up | 1.9885997667 |
| PubMed_21979375_A2 | Up | 1.1062068809 |
| GSE35957 | Up | 0.4694244700 |
| GSE36640 | Up | 2.4697235784 |
| GSE54402 | Up | 0.3181393517 |
| GSE9593 | Up | 0.7981525198 |
| GSE43922 | Up | 0.0912855097 |
| GSE24585 | Up | 0.2852838066 |
| GSE37065 | Up | 0.5477379639 |
| GSE28863_A1 | Up | 0.1284721469 |
| GSE28863_A2 | Up | 1.2483528508 |
| GSE28863_A3 | Down | -0.1599517707 |
| GSE28863_A4 | Down | -0.3867013328 |
| GSE48662 | Up | 0.3513281075 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-31-5p | MIMAT0000089 | MIRT007367 | Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23518389 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028971 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-941 | MIMAT0004984 | MIRT036577 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21263217 | CREG1 enhances p16(INK4a) -induced cellular senescence |
| 21263217 | Moreover, we found that repression of CREG1 expression occurs via an epigenetic mechanism, promoter DNA methylation |
| 21263217 | Ectopic expression of CREG1 in the immortal LFS cell lines decreases cell proliferation but does not directly induce senescence |
| 21263217 | In addition, we found that p16 (INK4a) is also downregulated in immortal cells and that coexpression of CREG1 and p16 (INK4a) , an inhibitor of CDK4/6 and Rb phosphorylation, has a greater effect than either CREG1 and p16 (INK4a) alone to reduce cell growth, induce cell cycle arrest and cellular senescence in immortal LFS fibroblasts, osteosarcoma and fibrosarcoma cell lines |
| 21263217 | Moreover, cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition |
| 21263217 | In conclusion, this is the first evidence to demonstrate that CREG1 enhances p16 (INK4a) -induced senescence by transcriptional repression of cell cycle-regulated genes |
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