HCSGD entry for TNFRSF10A

1. General information

Official gene symbolTNFRSF10A
Entrez ID8797
Gene full nametumor necrosis factor receptor superfamily, member 10a
Other gene symbolsAPO2 CD261 DR4 TRAILR-1 TRAILR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004872Receptor activityNASmolecular_function
GO:0005035Death receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0006915Apoptotic processNASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityNASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsNASbiological_process
GO:0016021Integral component of membraneICcellular_component
GO:0045569TRAIL bindingNASmolecular_function
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00037332930.75582226360.05182210531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6051858110
GSE13712_SHEARUp0.6604204627
GSE13712_STATICUp0.8962411833
GSE19018Down-0.3476527717
GSE19899_A1Up0.5439901771
GSE19899_A2Up3.3519058740
PubMed_21979375_A1Up3.2006966699
PubMed_21979375_A2Up3.7372441382
GSE35957Down-0.2226378614
GSE36640Up2.3100455371
GSE54402Up0.7337068753
GSE9593Up0.1204883090
GSE43922Up1.6929289821
GSE24585Down-0.0057734031
GSE37065Up0.2941622713
GSE28863_A1Down-0.6960114368
GSE28863_A2Down-0.2516262236
GSE28863_A3Down-0.6887319546
GSE28863_A4Up0.1848693829
GSE48662Up0.2116130475

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT001494pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT031670ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24551275Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53
24551275We reveal significant upregulation of the apoptosis-inducing ligand TRAIL and its cognate receptors DR4 and DR5 in AEC within active lesions of IPF lungs
24551275In contrast, myofibroblasts within the fibroblastic foci of IPF lungs exhibited high TRAIL, DR4 and DR5 expression but negligible p53 expression
24551275However, DR4 and DR5 upregulation was detected in IPF alveolar macrophages and lymphocytes
18202802Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells
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