HCSGD entry for TNFRSF10B

1. General information

Official gene symbolTNFRSF10B
Entrez ID8795
Gene full nametumor necrosis factor receptor superfamily, member 10b
Other gene symbolsCD262 DR5 KILLER KILLER/DR5 TRAIL-R2 TRAILR2 TRICK2 TRICK2A TRICK2B TRICKB ZTNFR9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004872Receptor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006915Apoptotic processNAS TASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityNASbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsNASbiological_process
GO:0016021Integral component of membraneICcellular_component
GO:0034976Response to endoplasmic reticulum stressIDAbiological_process
GO:0042981Regulation of apoptotic processNASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0045569TRAIL bindingNASmolecular_function
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMPbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:2001239Regulation of extrinsic apoptotic signaling pathway in absence of ligandTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00078412290.99898117850.07817765151.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2924478505
GSE13712_SHEARUp0.1466807079
GSE13712_STATICUp0.1143186322
GSE19018Down-0.0426619053
GSE19899_A1Up0.4650575818
GSE19899_A2Up1.5992142226
PubMed_21979375_A1Up0.7510335619
PubMed_21979375_A2Up1.2619563783
GSE35957Up0.3144183712
GSE36640Up1.2222832980
GSE54402Down-0.0220809063
GSE9593Up0.6392272658
GSE43922Up1.0832887406
GSE24585Up0.7718616327
GSE37065Up0.3690342042
GSE28863_A1Up0.7142034809
GSE28863_A2Up0.3739571768
GSE28863_A3Up0.2383217286
GSE28863_A4Up0.0856646868
GSE48662Up0.7147842304

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

HGS-TR2JDB05895 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT005122pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-340-5pMIMAT0004692MIRT019597SequencingFunctional MTI (Weak)20371350
hsa-miR-940MIMAT0004983MIRT036627CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043345CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049847CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050973CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26152738EXPERIMENTAL DESIGN: We combined treatment with an aurora kinase A inhibitor, MLN8237, with agents that activate death receptors (Apo2L/TRAIL or death receptor 5 agonists) and monitored the ability of this treatment to induce tumor apoptosis and melanoma tumor regression using human cell lines and patient-derived xenograft (PDX) mouse models
26152738Mechanistic analysis showed that the induction of tumor cell senescence in response to the AURKA inhibitor resulted in a decreased display of Apo2L/TRAIL decoy receptors and increased display of one Apo2L/TRAIL receptor (death receptor 5), resulting in enhanced response to death receptor ligand/agonists
26152738Melanoma tumor xenografts of one human cell line and one PDX displayed total blockage of tumor growth when treated with MLN8237 combined with DR5 agonist antibody
24551275Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53
24551275We reveal significant upregulation of the apoptosis-inducing ligand TRAIL and its cognate receptors DR4 and DR5 in AEC within active lesions of IPF lungs
24551275In contrast, myofibroblasts within the fibroblastic foci of IPF lungs exhibited high TRAIL, DR4 and DR5 expression but negligible p53 expression
24551275However, DR4 and DR5 upregulation was detected in IPF alveolar macrophages and lymphocytes
16951143In this study, we used chromatin immunoprecipitation to determine that p53 preferentially occupied the promoters of growth arrest genes p21 and GADD45 in senescent normal human diploid fibroblasts but not the promoters of other target genes that recruited p53 following doxorubicin-induced DNA damage, such as apoptosis regulators TNFRSF10b, TNFRSF6, and PUMA
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