HCSGD entry for DLK1
1. General information
| Official gene symbol | DLK1 |
|---|---|
| Entrez ID | 8788 |
| Gene full name | delta-like 1 homolog (Drosophila) |
| Other gene symbols | DLK DLK-1 Delta1 FA1 PREF1 Pref-1 ZOG pG2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0045746 | Negative regulation of Notch signaling pathway | IEA | biological_process |
| GO:0048706 | Embryonic skeletal system development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5386230310 | 0.1876934843 | 0.9999902473 | 0.8399991672 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1098004818 |
| GSE13712_SHEAR | Up | 0.0322827058 |
| GSE13712_STATIC | Down | -0.0312051587 |
| GSE19018 | Down | -0.2382979077 |
| GSE19899_A1 | Up | 0.0353762053 |
| GSE19899_A2 | Down | -3.2657749688 |
| PubMed_21979375_A1 | Up | 0.0469162553 |
| PubMed_21979375_A2 | Down | -0.5375876425 |
| GSE35957 | Down | -0.5897240658 |
| GSE36640 | Down | -0.3370547973 |
| GSE54402 | Up | 0.5021020307 |
| GSE9593 | Up | 0.0389675228 |
| GSE43922 | Up | 0.1487187786 |
| GSE24585 | Down | -0.0271466500 |
| GSE37065 | Down | -0.0332948681 |
| GSE28863_A1 | Up | 0.1007610926 |
| GSE28863_A2 | Up | 0.2680790914 |
| GSE28863_A3 | Up | 0.1960066745 |
| GSE28863_A4 | Down | -0.1127550728 |
| GSE48662 | Up | 0.1172211265 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | MIRT032077 | qRT-PCR;Other | Functional MTI (Weak) | 20385127 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25798129 | Additionally, zonation and regeneration of the adrenal cortex are controlled by developmental signaling pathways, such as the sonic hedgehog, delta-like homolog 1, fibroblast growth factor, and WNT/beta-catenin pathways |
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