HCSGD entry for RIPK2

1. General information

Official gene symbolRIPK2
Entrez ID8767
Gene full namereceptor-interacting serine-threonine kinase 2
Other gene symbolsCARD3 CARDIAK CCK GIG30 RICK RIP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001961Positive regulation of cytokine-mediated signaling pathwayIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002250Adaptive immune responseISSbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0002827Positive regulation of T-helper 1 type immune responseIEAbiological_process
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIDAcellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingISSbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0010800Positive regulation of peptidyl-threonine phosphorylationIDAbiological_process
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0030274LIM domain bindingIPImolecular_function
GO:0031398Positive regulation of protein ubiquitinationIMP NASbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0031982VesicleIDAcellular_component
GO:0032722Positive regulation of chemokine productionIEAbiological_process
GO:0032727Positive regulation of interferon-alpha productionNASbiological_process
GO:0032728Positive regulation of interferon-beta productionNASbiological_process
GO:0032729Positive regulation of interferon-gamma productionIEAbiological_process
GO:0032735Positive regulation of interleukin-12 productionNASbiological_process
GO:0032743Positive regulation of interleukin-2 productionIEAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEAbiological_process
GO:0033091Positive regulation of immature T cell proliferationIEAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayIDA TASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043330Response to exogenous dsRNAIEAbiological_process
GO:0045087Innate immune responseIDA ISS TASbiological_process
GO:0045627Positive regulation of T-helper 1 cell differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterNASbiological_process
GO:0046330Positive regulation of JNK cascadeIEAbiological_process
GO:0046641Positive regulation of alpha-beta T cell proliferationIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050700CARD domain bindingIDA IPImolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEAbiological_process
GO:0050852T cell receptor signaling pathwayISS TASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMP TASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0070427Nucleotide-binding oligomerization domain containing 1 signaling pathwayIEAbiological_process
GO:0070431Nucleotide-binding oligomerization domain containing 2 signaling pathwayIDAbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0070671Response to interleukin-12IEAbiological_process
GO:0070673Response to interleukin-18IEAbiological_process
GO:0071223Cellular response to lipoteichoic acidIEAbiological_process
GO:0071224Cellular response to peptidoglycanIEAbiological_process
GO:0071225Cellular response to muramyl dipeptideIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00223859660.15993799630.12701875000.7725874702

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.0075122118
GSE13712_SHEARUp0.2365069338
GSE13712_STATICUp0.6544507579
GSE19018Down-0.1725913237
GSE19899_A1Up0.8781336035
GSE19899_A2Up1.4000426863
PubMed_21979375_A1Up1.7993082362
PubMed_21979375_A2Up0.9985148412
GSE35957Down-0.5655803821
GSE36640Up0.7500371215
GSE54402Up1.8953496013
GSE9593Up0.0282186540
GSE43922Up0.7062406794
GSE24585Down-0.7240356808
GSE37065Up0.6137120193
GSE28863_A1Down-0.4253651845
GSE28863_A2Up0.2851360313
GSE28863_A3Down-1.1593742760
GSE28863_A4Down-0.2595384117
GSE48662Down-0.5740916660

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT024084MicroarrayFunctional MTI (Weak)18668037
hsa-miR-98-5pMIMAT0000096MIRT027839MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.