HCSGD entry for TNFRSF14

1. General information

Official gene symbolTNFRSF14
Entrez ID8764
Gene full nametumor necrosis factor receptor superfamily, member 14
Other gene symbolsATAR CD270 HVEA HVEM LIGHTR TR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001618Virus receptor activityIEAmolecular_function
GO:0002741Positive regulation of cytokine secretion involved in immune responseIEAbiological_process
GO:0005031Tumor necrosis factor-activated receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneICcellular_component
GO:0006955Immune responseTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0012501Programmed cell deathTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0033209Tumor necrosis factor-mediated signaling pathwayTASbiological_process
GO:0046642Negative regulation of alpha-beta T cell proliferationIEAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050829Defense response to Gram-negative bacteriumIEAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEAbiological_process
GO:2000406Positive regulation of T cell migrationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16828494360.72032361990.80908450601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3972752810
GSE13712_SHEARDown-0.5406607256
GSE13712_STATICUp0.0259520995
GSE19018Up0.3339076629
GSE19899_A1Up0.0230750608
GSE19899_A2Up0.3567404863
PubMed_21979375_A1Down-0.1331087090
PubMed_21979375_A2Up0.0071383170
GSE35957Down-0.4068221543
GSE36640Down-0.0989036635
GSE54402Down-0.2958602641
GSE9593Up0.6819326826
GSE43922Up0.1048003208
GSE24585Down-0.0900857566
GSE37065Up0.0954798017
GSE28863_A1Down-0.0352028781
GSE28863_A2Up0.3303946580
GSE28863_A3Up0.1412261343
GSE28863_A4Up0.1077405036
GSE48662Up0.2036567940

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

6345690High-voltage electron microscopy (HVEM) after detergent extraction of human epidermal keratinocyte (HK) colonies grown in the defined medium with low and high calcium has revealed specific changes in the intermediate filament network and keratohyalin granules corresponding to changes in cellular differentiation
6345690Indirect immunofluorescence studies have verified that the intermediate filament network observed with HVEM is composed of keratin proteins
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