HCSGD entry for CBS
1. General information
| Official gene symbol | CBS |
|---|---|
| Entrez ID | 875 |
| Gene full name | cystathionine-beta-synthase |
| Other gene symbols | HIP4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000096 | Sulfur amino acid metabolic process | TAS | biological_process |
| GO:0001958 | Endochondral ossification | IEA | biological_process |
| GO:0001974 | Blood vessel remodeling | IEA | biological_process |
| GO:0004122 | Cystathionine beta-synthase activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006535 | Cysteine biosynthetic process from serine | IEA | biological_process |
| GO:0006563 | L-serine metabolic process | IDA | biological_process |
| GO:0006565 | L-serine catabolic process | IDA | biological_process |
| GO:0006801 | Superoxide metabolic process | IEA | biological_process |
| GO:0019343 | Cysteine biosynthetic process via cystathionine | IEA | biological_process |
| GO:0019346 | Transsulfuration | IEA TAS | biological_process |
| GO:0019448 | L-cysteine catabolic process | IDA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0020037 | Heme binding | IDA IMP | molecular_function |
| GO:0021587 | Cerebellum morphogenesis | IEA | biological_process |
| GO:0030170 | Pyridoxal phosphate binding | IDA | molecular_function |
| GO:0030554 | Adenyl nucleotide binding | IEA | molecular_function |
| GO:0030823 | Regulation of cGMP metabolic process | IEA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043418 | Homocysteine catabolic process | IDA | biological_process |
| GO:0043506 | Regulation of JUN kinase activity | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050667 | Homocysteine metabolic process | IDA | biological_process |
| GO:0050880 | Regulation of blood vessel size | IEA | biological_process |
| GO:0051593 | Response to folic acid | IEA | biological_process |
| GO:0060135 | Maternal process involved in female pregnancy | IEA | biological_process |
| GO:0060351 | Cartilage development involved in endochondral bone morphogenesis | IEA | biological_process |
| GO:0070814 | Hydrogen sulfide biosynthetic process | IDA IEA ISS | biological_process |
| GO:0071456 | Cellular response to hypoxia | IEA | biological_process |
| GO:0072341 | Modified amino acid binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7092704001 | 0.0050513734 | 0.9999902473 | 0.1452614629 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4545721460 |
| GSE13712_SHEAR | Up | 0.5019422927 |
| GSE13712_STATIC | Up | 0.0978857073 |
| GSE19018 | Up | 0.6230322494 |
| GSE19899_A1 | Down | -0.4491583058 |
| GSE19899_A2 | Down | -1.0975522071 |
| PubMed_21979375_A1 | Down | -0.6743048549 |
| PubMed_21979375_A2 | Down | -1.6911048565 |
| GSE35957 | Down | -0.6001917024 |
| GSE36640 | Down | -0.7676652810 |
| GSE54402 | Down | -0.7186235246 |
| GSE9593 | Up | 0.1905667407 |
| GSE43922 | Down | -0.9959396241 |
| GSE24585 | Up | 0.3317789180 |
| GSE37065 | Down | -0.9290267188 |
| GSE28863_A1 | Up | 0.1404195475 |
| GSE28863_A2 | Down | -0.4512856835 |
| GSE28863_A3 | Down | -0.3408247936 |
| GSE28863_A4 | Up | 0.0460737647 |
| GSE48662 | Up | 0.3789173407 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Cysteine | DB00151 | NUTR00018 | DB04443 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038567 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039571 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040018 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041577 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043169 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045521 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049293 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
