HCSGD entry for RIPK1

1. General information

Official gene symbolRIPK1
Entrez ID8737
Gene full namereceptor (TNFRSF)-interacting serine-threonine kinase 1
Other gene symbolsRIP RIP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIDA IMPmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0005123Death receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processIMP TASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0007257Activation of JUN kinase activityTASbiological_process
GO:0010940Positive regulation of necrotic cell deathIMPbiological_process
GO:0031264Death-inducing signaling complexIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIDAbiological_process
GO:0033209Tumor necrosis factor-mediated signaling pathwayICbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034612Response to tumor necrosis factorIMPbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0036289Peptidyl-serine autophosphorylationIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043065Positive regulation of apoptotic processIDA IMPbiological_process
GO:0043068Positive regulation of programmed cell deathIMPbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDA IEPbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0044257Cellular protein catabolic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045651Positive regulation of macrophage differentiationIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0051291Protein heterooligomerizationIMPbiological_process
GO:0060545Positive regulation of necroptotic processIMPbiological_process
GO:0070231T cell apoptotic processISSbiological_process
GO:0070266Necroptotic processIMPbiological_process
GO:0070513Death domain bindingIPImolecular_function
GO:0070926Regulation of ATP:ADP antiporter activityIMPbiological_process
GO:0071356Cellular response to tumor necrosis factorIDAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDA IMPbiological_process
GO:0097342RipoptosomeIDAcellular_component
GO:0097343Ripoptosome assemblyIMPbiological_process
GO:0097527Necroptotic signaling pathwayIMPbiological_process
GO:1990000Amyloid fibril formationIMPbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processTASbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIMPbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIMPbiological_process
GO:2001239Regulation of extrinsic apoptotic signaling pathway in absence of ligandTASbiological_process
GO:2001243Negative regulation of intrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04288136470.84620804300.46162833201.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0559891342
GSE13712_SHEARUp0.3765408626
GSE13712_STATICUp0.1739986006
GSE19018Down-0.1808760562
GSE19899_A1Up0.0079676554
GSE19899_A2Up0.5604944456
PubMed_21979375_A1Down-0.0802047666
PubMed_21979375_A2Up0.6744697089
GSE35957Down-0.2237081162
GSE36640Down-0.0737650970
GSE54402Up0.4335329003
GSE9593Up0.4431260376
GSE43922Up0.0250941182
GSE24585Up1.4779461706
GSE37065Up0.1668624659
GSE28863_A1Up0.3259142910
GSE28863_A2Up0.6561370936
GSE28863_A3Down-0.3119009453
GSE28863_A4Down-0.2094062259
GSE48662Down-0.3060598286

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.