HCSGD entry for CTNNAL1
1. General information
| Official gene symbol | CTNNAL1 |
|---|---|
| Entrez ID | 8727 |
| Gene full name | catenin (cadherin-associated protein), alpha-like 1 |
| Other gene symbols | CLLP alpha-CATU |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007266 | Rho protein signal transduction | IDA | biological_process |
| GO:0015629 | Actin cytoskeleton | IEA | cellular_component |
| GO:0045296 | Cadherin binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7884443410 | 0.0170328103 | 0.9999902473 | 0.2556380844 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2461696842 |
| GSE13712_SHEAR | Up | 0.2951952388 |
| GSE13712_STATIC | Up | 0.2371238538 |
| GSE19018 | Up | 0.1690586060 |
| GSE19899_A1 | Down | -0.8505070794 |
| GSE19899_A2 | Down | -0.4928069201 |
| PubMed_21979375_A1 | Down | -0.6192304405 |
| PubMed_21979375_A2 | Down | -0.9792448169 |
| GSE35957 | Up | 0.2958036299 |
| GSE36640 | Down | -1.2145444586 |
| GSE54402 | Down | -0.5062758232 |
| GSE9593 | Down | -0.0303273837 |
| GSE43922 | Down | -0.5040621839 |
| GSE24585 | Up | 0.0758846243 |
| GSE37065 | Down | -0.4966205984 |
| GSE28863_A1 | Up | 0.5039576523 |
| GSE28863_A2 | Up | 0.0603252729 |
| GSE28863_A3 | Down | -0.3322791611 |
| GSE28863_A4 | Up | 0.1250763227 |
| GSE48662 | Down | -0.2559486610 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320a | MIMAT0000510 | MIRT044401 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23047866 | Here, we report that alpha-catulin also drives malignant invasion and metastasis |
| 23047866 | Attenuation of ILK or alpha-catulin reciprocally blocked cell migration and invasion induced by the other protein |
| 23047866 | Mechanistic investigations revealed that alpha-catulin activated Akt-NF-kappaB signaling downstream of ILK, which in turn led to increased expression of fibronectin and integrin alphavbeta3 |
| 23047866 | Clinically, high levels of expression of alpha-catulin and ILK were associated with poor overall survival in patients with NSCLC |
| 23047866 | Taken together, our study shows that alpha-catulin plays a critical role in cancer metastasis by activating the ILK-mediated Akt-NF-kappaB-alphavbeta3 signaling axis |
| 21278790 | Here, we found that alpha-catulin mRNA levels were significantly upregulated in cancer cell lines and clinical oral squamous cell carcinomas, which positively correlated with tumor size (P=0 |
| 21278790 | Mechanistic dissection showed that alpha-catulin depletion strongly induced the DNA-damage response (DDR) in both cell lines, via a p53/p21-dependent pathway in A549 cells, but a p53/p21-independent pathway in OC2 cells carrying mutant p53 |
| 21278790 | Global gene expression analysis revealed that alpha-catulin knockdown altered cell-cycle regulation and DDR pathways at the presenescent stage as well as significantly downregulate several crucial genes related to mitotic chromosome condensation, DDR and DNA repair systems, which suggests that its depletion-induced cellular senescence might be caused by chromosome condensation failures, severe DNA damage and impaired DNA repair ability |
| 21278790 | Our study provides evidence that alpha-catulin promotes tumor growth by preventing cellular senescence and suggests that downregulating alpha-catulin may be a promising therapeutic approach for cancer treatment |
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