HCSGD entry for EED
1. General information
| Official gene symbol | EED |
|---|---|
| Entrez ID | 8726 |
| Gene full name | embryonic ectoderm development |
| Other gene symbols | HEED WAIT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001739 | Sex chromatin | IEA | cellular_component |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | NAS | cellular_component |
| GO:0006349 | Regulation of gene expression by genetic imprinting | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016571 | Histone methylation | IEA | biological_process |
| GO:0035098 | ESC/E(Z) complex | IDA IEA | cellular_component |
| GO:0042054 | Histone methyltransferase activity | IDA | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045120 | Pronucleus | IEA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0061087 | Positive regulation of histone H3-K27 methylation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2046822195 | 0.7534015349 | 0.8726013443 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1750838924 |
| GSE13712_SHEAR | Up | 0.2518860463 |
| GSE13712_STATIC | Up | 0.1042269180 |
| GSE19018 | Down | -0.1467777099 |
| GSE19899_A1 | Up | 0.1563053074 |
| GSE19899_A2 | Down | -0.3546819319 |
| PubMed_21979375_A1 | Up | 0.5480195807 |
| PubMed_21979375_A2 | Up | 0.1510687468 |
| GSE35957 | Down | -0.3363548204 |
| GSE36640 | Down | -0.6743085238 |
| GSE54402 | Up | 0.1781408825 |
| GSE9593 | Down | -0.2336934727 |
| GSE43922 | Up | 0.0916275817 |
| GSE24585 | Up | 0.0980012970 |
| GSE37065 | Up | 0.1579653330 |
| GSE28863_A1 | Up | 0.3265394499 |
| GSE28863_A2 | Up | 0.3472339253 |
| GSE28863_A3 | Down | -0.2232473004 |
| GSE28863_A4 | Up | 0.2340814989 |
| GSE48662 | Down | -0.1501508692 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-101-3p | MIMAT0000099 | MIRT004086 | Western blot | Functional MTI | 19008416 |
| hsa-miR-138-5p | MIMAT0000430 | MIRT021689 | Western blot;qRT-PCR | Non-Functional MTI | 21770894 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029750 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT048018 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24217920 | We show that SA-miRNAs-26b, 181a, 210 and 424 function in concert to directly repress expression of Polycomb group (PcG) proteins CBX7, embryonic ectoderm development (EED), enhancer of zeste homologue 2 (EZH2) and suppressor of zeste 12 homologue (Suz12), thereby activating p16 |
| 23788032 | It is known that the histone methyltransferase enhancer of zeste homolog 2 (EZH2) and embryonic ectoderm development (EED) are direct targets of miR-101 |
| 23788032 | The epigenetic regulation of H3K27me3 on CPEB1 promoter is mediated by EZH2 and EED |
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