HCSGD entry for TRADD

1. General information

Official gene symbolTRADD
Entrez ID8717
Gene full nameTNFRSF1A-associated via death domain
Other gene symbolsHs.89862
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004871Signal transducer activityIEAmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsTASbiological_process
GO:0019900Kinase bindingIPImolecular_function
GO:0031264Death-inducing signaling complexTAScellular_component
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033209Tumor necrosis factor-mediated signaling pathwayTASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEA IEPbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0045121Membrane raftIEAcellular_component
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051798Positive regulation of hair follicle developmentIEAbiological_process
GO:0060090Binding, bridgingIPImolecular_function
GO:0070513Death domain bindingIPImolecular_function
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIMP TASbiological_process
GO:2001239Regulation of extrinsic apoptotic signaling pathway in absence of ligandTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20631365450.92269672120.87558556921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0414371528
GSE13712_SHEARUp0.0383540350
GSE13712_STATICUp0.3078762916
GSE19018Up0.3171733173
GSE19899_A1Down-0.1490259100
GSE19899_A2Up0.6325430397
PubMed_21979375_A1Up0.1728863510
PubMed_21979375_A2Up0.1215838513
GSE35957Up0.0216600588
GSE36640Up0.4774424066
GSE54402Down-0.0147033839
GSE9593Up0.1654972810
GSE43922Up0.0484264695
GSE24585Up0.1892089935
GSE37065Up0.1410098998
GSE28863_A1Down-0.3186936360
GSE28863_A2Down-0.0257935300
GSE28863_A3Down-0.2943820904
GSE28863_A4Up0.1859953801
GSE48662Up0.0819155902

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21212468Zfra (zinc finger-like protein that regulates apoptosis) is a naturally occurring short peptide consisting of 31 amino acids, which regulates tumor necrosis factor (TNF)-mediated cell death by interacting with receptor adaptor protein TRADD (TNF receptorassociated death domain protein) and downstream JNK (c-Jun N-terminal kinase), NF-kappaB (Nuclear factor kappa B) and WWOX/WOX1 (WW domain-containing oxidoreductase)
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