HCSGD entry for SERPINH1
1. General information
| Official gene symbol | SERPINH1 |
|---|---|
| Entrez ID | 871 |
| Gene full name | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) |
| Other gene symbols | AsTP3 CBP1 CBP2 HSP47 OI10 PPROM RA-A47 SERPINH2 gp46 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IBA | molecular_function |
| GO:0005518 | Collagen binding | NAS | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA IEA NAS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005793 | Endoplasmic reticulum-Golgi intermediate compartment | IDA | cellular_component |
| GO:0006986 | Response to unfolded protein | TAS | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0030162 | Regulation of proteolysis | IBA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030199 | Collagen fibril organization | IEA | biological_process |
| GO:0032964 | Collagen biosynthetic process | IEA | biological_process |
| GO:0051082 | Unfolded protein binding | IEA | molecular_function |
| GO:0051604 | Protein maturation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9875159112 | 0.0010954029 | 0.9999902473 | 0.0629521834 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6920054990 |
| GSE13712_SHEAR | Down | -0.1426254558 |
| GSE13712_STATIC | Down | -0.3027903995 |
| GSE19018 | Down | -0.1245311594 |
| GSE19899_A1 | Down | -1.9204928755 |
| GSE19899_A2 | Down | -1.4240968568 |
| PubMed_21979375_A1 | Down | -1.7564764304 |
| PubMed_21979375_A2 | Down | -2.1025424881 |
| GSE35957 | Down | -0.6024048903 |
| GSE36640 | Down | -0.5844934458 |
| GSE54402 | Down | -0.7695400652 |
| GSE9593 | Down | -0.5736045402 |
| GSE43922 | Down | -0.6593766791 |
| GSE24585 | Up | 0.4133742200 |
| GSE37065 | Down | -0.8432549234 |
| GSE28863_A1 | Up | 0.4246305406 |
| GSE28863_A2 | Up | 0.0012549004 |
| GSE28863_A3 | Down | -0.2125820243 |
| GSE28863_A4 | Up | 0.0035420163 |
| GSE48662 | Down | -0.0530664223 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022927 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029883 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-484 | MIMAT0002174 | MIRT041847 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26690900 | STUDY HYPOTHESIS: In women with preterm premature rupture of the membranes (PPROM), increased oxidative stress may accelerate premature cellular senescence, senescence-associated inflammation and proteolysis, which may predispose them to rupture |
| 26690900 | The markers of senescence that we tested are specific but are not sufficient to confirm senescence as the pathology in PPROM |
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