HCSGD entry for ACTN1

1. General information

Official gene symbolACTN1
Entrez ID87
Gene full nameactinin, alpha 1
Other gene symbolsBDPLT15
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIEAcellular_component
GO:0002576Platelet degranulationTASbiological_process
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003779Actin bindingIEAmolecular_function
GO:0005178Integrin bindingIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005916Fascia adherensIEAcellular_component
GO:0005925Focal adhesionIMPcellular_component
GO:0007596Blood coagulationTASbiological_process
GO:0017166Vinculin bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030018Z discIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031143PseudopodiumTAScellular_component
GO:0034329Cell junction assemblyTASbiological_process
GO:0042981Regulation of apoptotic processNASbiological_process
GO:0042995Cell projectionIDAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0044325Ion channel bindingIPImolecular_function
GO:0048041Focal adhesion assemblyIMPbiological_process
GO:0051015Actin filament bindingIEAmolecular_function
GO:0051017Actin filament bundle assemblyIEAbiological_process
GO:0051271Negative regulation of cellular component movementIMPbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85814219060.07672673910.99999024730.5235998185

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8680807388
GSE13712_SHEARDown-0.2214712544
GSE13712_STATICDown-0.0331938020
GSE19018Down-0.0050379782
GSE19899_A1Down-0.5224679683
GSE19899_A2Down-0.1306756522
PubMed_21979375_A1Up0.3693346956
PubMed_21979375_A2Down-0.5506770045
GSE35957Up0.0240875496
GSE36640Up0.1506856163
GSE54402Down-0.0189855479
GSE9593Down-0.0375543027
GSE43922Down-0.0051426039
GSE24585Up0.2360617186
GSE37065Down-0.3041707631
GSE28863_A1Up0.0940626610
GSE28863_A2Up0.1626113019
GSE28863_A3Down-0.2736016395
GSE28863_A4Down-0.0431067965
GSE48662Up0.1397557435

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-218-5pMIMAT0000275MIRT005004Luciferase reporter assay//qRT-PCRNon-Functional MTI19890957
hsa-miR-193b-3pMIMAT0002819MIRT016362ProteomicsFunctional MTI (Weak)21512034
hsa-miR-1MIMAT0000416MIRT023743Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-93-3pMIMAT0004509MIRT038768CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039867CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051157CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.