HCSGD entry for CBLB

1. General information

Official gene symbolCBLB
Entrez ID868
Gene full nameCbl proto-oncogene, E3 ubiquitin protein ligase B
Other gene symbolsCbl-b RNF56
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001784Phosphotyrosine bindingIEAmolecular_function
GO:0002669Positive regulation of T cell anergyIEAbiological_process
GO:0004842Ubiquitin-protein ligase activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006607NLS-bearing protein import into nucleusTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0023051Regulation of signalingIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0045732Positive regulation of protein catabolic processIEAbiological_process
GO:0046642Negative regulation of alpha-beta T cell proliferationIEAbiological_process
GO:0050860Negative regulation of T cell receptor signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06709491660.14296693130.55794638460.7287049961

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4497694701
GSE13712_SHEARUp0.0682357618
GSE13712_STATICDown-0.2794800076
GSE19018Up0.2125495070
GSE19899_A1Up0.6355272302
GSE19899_A2Up0.1138689957
PubMed_21979375_A1Up2.1818099053
PubMed_21979375_A2Up0.7951728511
GSE35957Down-0.0985307988
GSE36640Up0.3891799243
GSE54402Up0.3897934744
GSE9593Down-0.1655102337
GSE43922Up1.1713864493
GSE24585Up0.1506400452
GSE37065Down-0.1417189467
GSE28863_A1Down-0.2171553608
GSE28863_A2Down-0.3273043906
GSE28863_A3Down-0.4397091425
GSE28863_A4Down-0.7822474307
GSE48662Down-0.1098224205

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.