HCSGD entry for VAMP8
1. General information
| Official gene symbol | VAMP8 |
|---|---|
| Entrez ID | 8673 |
| Gene full name | vesicle-associated membrane protein 8 |
| Other gene symbols | EDB VAMP-8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000046 | Autophagic vacuole fusion | IMP | biological_process |
| GO:0000149 | SNARE binding | IBA | molecular_function |
| GO:0005484 | SNAP receptor activity | IBA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA IEA | cellular_component |
| GO:0005769 | Early endosome | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006461 | Protein complex assembly | IEA | biological_process |
| GO:0006887 | Exocytosis | IBA | biological_process |
| GO:0006892 | Post-Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0006897 | Endocytosis | IBA | biological_process |
| GO:0006906 | Vesicle fusion | IBA IEA | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016192 | Vesicle-mediated transport | IEA | biological_process |
| GO:0019905 | Syntaxin binding | IEA | molecular_function |
| GO:0030100 | Regulation of endocytosis | IEA | biological_process |
| GO:0030141 | Secretory granule | IEA | cellular_component |
| GO:0030667 | Secretory granule membrane | TAS | cellular_component |
| GO:0031201 | SNARE complex | IDA IEA | cellular_component |
| GO:0031902 | Late endosome membrane | IDA IEA | cellular_component |
| GO:0055037 | Recycling endosome | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7484487519 | 0.0029183200 | 0.9999902473 | 0.1078835674 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2228750481 |
| GSE13712_SHEAR | Down | -4.8949470275 |
| GSE13712_STATIC | Down | -4.7757010388 |
| GSE19018 | Up | 0.2693859191 |
| GSE19899_A1 | Up | 0.2491941008 |
| GSE19899_A2 | Down | -0.4506662369 |
| PubMed_21979375_A1 | Down | -0.0918183529 |
| PubMed_21979375_A2 | Down | -0.0448816749 |
| GSE35957 | Down | -2.3998538538 |
| GSE36640 | Down | -0.2017277683 |
| GSE54402 | Down | -0.7567059572 |
| GSE9593 | Down | -0.6829092427 |
| GSE43922 | Down | -0.1585827360 |
| GSE24585 | Up | 0.1115986772 |
| GSE37065 | Up | 0.1150994194 |
| GSE28863_A1 | Down | -0.2267072285 |
| GSE28863_A2 | Down | -0.2928742332 |
| GSE28863_A3 | Up | 0.2147876737 |
| GSE28863_A4 | Up | 0.3156422632 |
| GSE48662 | Down | -0.0129606733 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016522 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016522 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022696 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025757 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031767 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10212139 | Pre-fibronectin mRNA is subject to alternative splicing at three sites, EDA, EDB and IIICS |
| 10212139 | About 80% of the cells produced both (+) and (-) forms of the mRNA at the EDA and EDB sites, and the remaining cells contained either the (+) or (-) form |
| 1713586 | Whereas fibronectin mRNAs from adult rat tissues were found to range from 0 to 25% ED-A+ and from 0 to 10% ED-B+, fibronectin mRNAs from cultured cell lines were found to be approximately 50-60% ED-A+ and 15-25% ED-B+ |
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