HCSGD entry for CBL

1. General information

Official gene symbolCBL
Entrez ID867
Gene full nameCbl proto-oncogene, E3 ubiquitin protein ligase
Other gene symbolsC-CBL CBL2 FRA11B NSLL RNF55
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001784Phosphotyrosine bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0004842Ubiquitin-protein ligase activityTASmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIMPbiological_process
GO:0016567Protein ubiquitinationTASbiological_process
GO:0016600Flotillin complexISScellular_component
GO:0017124SH3 domain bindingIPImolecular_function
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0046875Ephrin receptor bindingIPImolecular_function
GO:0048260Positive regulation of receptor-mediated endocytosisTASbiological_process
GO:2001141Regulation of RNA biosynthetic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04439001940.81731722960.46937791161.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0373347888
GSE13712_SHEARUp0.3857707479
GSE13712_STATICUp0.2333998263
GSE19018Up0.0320048573
GSE19899_A1Up0.1275122169
GSE19899_A2Up0.3605640202
PubMed_21979375_A1Up0.5326272254
PubMed_21979375_A2Up0.7420070856
GSE35957Down-0.1811368851
GSE36640Down-0.4065844777
GSE54402Up0.5338935943
GSE9593Down-0.1242164163
GSE43922Up0.2715768491
GSE24585Up0.1967223220
GSE37065Up0.1910770459
GSE28863_A1Up0.5452489306
GSE28863_A2Up0.8355848852
GSE28863_A3Down-0.5197120279
GSE28863_A4Down-0.0254860110
GSE48662Down-0.7679020194

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT050866CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051757CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.