HCSGD entry for EIF3B
1. General information
| Official gene symbol | EIF3B |
|---|---|
| Entrez ID | 8662 |
| Gene full name | eukaryotic translation initiation factor 3, subunit B |
| Other gene symbols | EIF3-ETA EIF3-P110 EIF3-P116 EIF3S9 PRT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0001731 | Formation of translation preinitiation complex | IEA | biological_process |
| GO:0003743 | Translation initiation factor activity | IC IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005852 | Eukaryotic translation initiation factor 3 complex | IDA IEA | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | IC IDA TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | IDA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016282 | Eukaryotic 43S preinitiation complex | IEA | cellular_component |
| GO:0031369 | Translation initiation factor binding | IEA | molecular_function |
| GO:0032947 | Protein complex scaffold | TAS | molecular_function |
| GO:0033290 | Eukaryotic 48S preinitiation complex | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4378900992 | 0.1940893431 | 0.9999902473 | 0.8535715288 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3330634200 |
| GSE13712_SHEAR | Up | 0.2128866577 |
| GSE13712_STATIC | Up | 0.0597632270 |
| GSE19018 | Down | -0.1300747585 |
| GSE19899_A1 | Up | 0.1443873788 |
| GSE19899_A2 | Up | 0.3899127614 |
| PubMed_21979375_A1 | Up | 0.3965848746 |
| PubMed_21979375_A2 | Up | 0.7371259863 |
| GSE35957 | Down | -0.4011317851 |
| GSE36640 | Down | -0.3362912734 |
| GSE54402 | Up | 0.1569699125 |
| GSE9593 | Down | -0.2760875209 |
| GSE43922 | Up | 0.2594701864 |
| GSE24585 | Down | -0.4755450179 |
| GSE37065 | Down | -0.3458864328 |
| GSE28863_A1 | Up | 0.1176614220 |
| GSE28863_A2 | Up | 0.4500857537 |
| GSE28863_A3 | Down | -0.4104869386 |
| GSE28863_A4 | Down | -0.2022292192 |
| GSE48662 | Down | -0.1144526400 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022932 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036964 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039779 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042468 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042887 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT043600 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046746 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049064 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
