HCSGD entry for ALDH4A1
1. General information
| Official gene symbol | ALDH4A1 |
|---|---|
| Entrez ID | 8659 |
| Gene full name | aldehyde dehydrogenase 4 family, member A1 |
| Other gene symbols | ALDH4 P5CD P5CDh |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003842 | 1-pyrroline-5-carboxylate dehydrogenase activity | EXP | molecular_function |
| GO:0004029 | Aldehyde dehydrogenase (NAD) activity | TAS | molecular_function |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006560 | Proline metabolic process | TAS | biological_process |
| GO:0006561 | Proline biosynthetic process | IEA | biological_process |
| GO:0006562 | Proline catabolic process | TAS | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0010133 | Proline catabolic process to glutamate | IEA | biological_process |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0019470 | 4-hydroxyproline catabolic process | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2282205197 | 0.1797608222 | 0.9100124678 | 0.8209970165 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0895299258 |
| GSE13712_SHEAR | Down | -0.5847549164 |
| GSE13712_STATIC | Down | -0.0045284545 |
| GSE19018 | Up | 0.2125244172 |
| GSE19899_A1 | Down | -0.2783523293 |
| GSE19899_A2 | Down | -0.3595659469 |
| PubMed_21979375_A1 | Down | -0.8327998330 |
| PubMed_21979375_A2 | Down | -0.0902273408 |
| GSE35957 | Up | 0.0555610022 |
| GSE36640 | Up | 0.1124106103 |
| GSE54402 | Down | -0.2880368235 |
| GSE9593 | Up | 0.5202318429 |
| GSE43922 | Up | 0.0530699297 |
| GSE24585 | Up | 0.1799960651 |
| GSE37065 | Down | -0.2638010139 |
| GSE28863_A1 | Up | 0.0245595357 |
| GSE28863_A2 | Down | -0.0554417942 |
| GSE28863_A3 | Up | 0.5856572448 |
| GSE28863_A4 | Up | 0.2138894830 |
| GSE48662 | Up | 0.3880701900 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT022075 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
