HCSGD entry for NCOA1

1. General information

Official gene symbolNCOA1
Entrez ID8648
Gene full namenuclear receptor coactivator 1
Other gene symbolsF-SRC-1 KAT13A RIP160 SRC1 bHLHe42 bHLHe74
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000435Positive regulation of transcription from RNA polymerase II promoter by galactoseIDAbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0001012RNA polymerase II regulatory region DNA bindingIEAmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityNASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003713Transcription coactivator activityIDA IEA NASmolecular_function
GO:0004402Histone acetyltransferase activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIDAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterNASbiological_process
GO:0007595LactationIEAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0016922Ligand-dependent nuclear receptor bindingIPImolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0021549Cerebellum developmentIEAbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021854Hypothalamus developmentIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030331Estrogen receptor bindingIEAmolecular_function
GO:0030374Ligand-dependent nuclear receptor transcription coactivator activityIDAmolecular_function
GO:0030521Androgen receptor signaling pathwayNASbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032526Response to retinoic acidIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0033142Progesterone receptor bindingIEAmolecular_function
GO:0035257Nuclear hormone receptor bindingIDA IEAmolecular_function
GO:0043005Neuron projectionIEAcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043967Histone H4 acetylationIEAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA NASbiological_process
GO:0045925Positive regulation of female receptivityIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA NASbiological_process
GO:0046965Retinoid X receptor bindingIEAmolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050681Androgen receptor bindingNASmolecular_function
GO:0060179Male mating behaviorIEAbiological_process
GO:0060206Estrous cycle phaseIEAbiological_process
GO:0060713Labyrinthine layer morphogenesisIEAbiological_process
GO:2001038Regulation of cellular response to drugIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62752706960.06985425330.99999024730.4988154639

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1000902714
GSE13712_SHEARDown-0.4087833877
GSE13712_STATICDown-0.2741657174
GSE19018Down-0.1599930655
GSE19899_A1Down-0.3958648918
GSE19899_A2Down-0.6120803159
PubMed_21979375_A1Down-0.1408526560
PubMed_21979375_A2Up0.1429155793
GSE35957Up0.1082728654
GSE36640Up0.4822922506
GSE54402Down-0.2986855237
GSE9593Up0.3430298389
GSE43922Down-0.4456937798
GSE24585Down-0.2147984418
GSE37065Up0.1033472834
GSE28863_A1Up0.6069281211
GSE28863_A2Up0.7726313614
GSE28863_A3Down-0.2565975105
GSE28863_A4Down-0.3951638108
GSE48662Down-0.2105967018

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1808264CHEMBL16153878Q15788
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  • Drugs

Name

Drug

Accession number

GenisteinDB01645 EXPT01582
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONEDB04652 -
2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OLDB06832 -
3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILEDB06875 -
(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACIDDB06908 -
[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILEDB06927 -
2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OLDB07009 -
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDEDB07080 -
1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOLDB07119 -
4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIMEDB07150 -
5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILEDB07198 -
2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACIDDB07215 -
3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONEDB07230 -
3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OLDB07236 -
(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diolDB07530 -
(5BETA)-PREGNANE-3,20-DIONEDB07557 -
3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acidDB07724 -
(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acidDB08220 -
MYRISTIC ACIDDB08231 -
1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)DB08742 -
AleglitazarDB08915 DB08483

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7d-5pMIMAT0000065MIRT051725CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

12511612Role of the promyelocytic leukemia body in the dynamic interaction between the androgen receptor and steroid receptor coactivator-1 in living cells
12511612Laser scanning confocal imaging of transfected cells expressing fluorescently labeled SRC-1 revealed that in an unsynchronized cell population, the coactivator is distributed in approximately 40% cells as nuclear bodies of 0
12511612Some of these satellite bodies contain the SRC-1
12511612Results of the relative half-times (t(1/2)) of replacement of YFP-SRC1 within the photobleached region of a single PML body from its surrounding nuclear space supported the conclusion that SRC-1 is actively transported from the PML bodies to the intranuclear filamentous structure by the ligand-activated AR
12511612This observation also suggests an interaction between AR and SRC-1 before its binding to the target gene
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