HCSGD entry for ABCB11

1. General information

Official gene symbolABCB11
Entrez ID8647
Gene full nameATP-binding cassette, sub-family B (MDR/TAP), member 11
Other gene symbolsABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIBAcellular_component
GO:0005215Transporter activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006200ATP catabolic processIBA TASbiological_process
GO:0006699Bile acid biosynthetic processTASbiological_process
GO:0006810TransportTASbiological_process
GO:0006812Cation transportTASbiological_process
GO:0006869Lipid transportIBA TASbiological_process
GO:0008206Bile acid metabolic processTASbiological_process
GO:0008554Sodium-exporting ATPase activity, phosphorylative mechanismTASmolecular_function
GO:0015126Canalicular bile acid transmembrane transporter activityIBAmolecular_function
GO:0015432Bile acid-exporting ATPase activityTASmolecular_function
GO:0015672Monovalent inorganic cation transportTASbiological_process
GO:0015721Bile acid and bile salt transportTASbiological_process
GO:0015722Canalicular bile acid transportIBAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIBAcellular_component
GO:0016324Apical plasma membraneIBAcellular_component
GO:0030001Metal ion transportTASbiological_process
GO:0034220Ion transmembrane transportIBA TASbiological_process
GO:0035725Sodium ion transmembrane transportTASbiological_process
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIBAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046581Intercellular canaliculusIBAcellular_component
GO:0055085Transmembrane transportIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69991444470.91949922120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0891074645
GSE13712_SHEARDown-0.0336058270
GSE13712_STATICDown-0.0389211300
GSE19018Up0.0922984330
GSE19899_A1Up0.0123289641
GSE19899_A2Up0.1240313408
PubMed_21979375_A1Up0.0924904617
PubMed_21979375_A2Down-0.1048641584
GSE35957Up0.0694540077
GSE36640Up0.0203077122
GSE54402Up0.0159743230
GSE9593Up0.0770910052
GSE43922Up0.0090037519
GSE24585Up0.0850004213
GSE37065Up0.0018912938
GSE28863_A1Up0.0450624992
GSE28863_A2Up0.0552969603
GSE28863_A3Up0.0678413817
GSE28863_A4Up0.1042648806
GSE48662Up0.0415020212

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
ClofazimineDB00845 APRD00278

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-33a-5pMIMAT0000091MIRT006901Luciferase reporter assay//qRT-PCRFunctional MTI22767443
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.