HCSGD entry for AKR1C3

1. General information

Official gene symbolAKR1C3
Entrez ID8644
Gene full namealdo-keto reductase family 1, member C3
Other gene symbolsDD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000060Protein import into nucleus, translocationIDAbiological_process
GO:0001523Retinoid metabolic processTASbiological_process
GO:0001758Retinal dehydrogenase activityIDAmolecular_function
GO:0004032Alditol:NADP+ 1-oxidoreductase activityIDAmolecular_function
GO:0004033Aldo-keto reductase (NADP) activityTASmolecular_function
GO:0004745Retinol dehydrogenase activityIDAmolecular_function
GO:0004958Prostaglandin F receptor activityIDAmolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006693Prostaglandin metabolic processIEP TASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007584Response to nutrientIEPbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008202Steroid metabolic processIEPbiological_process
GO:0008284Positive regulation of cell proliferationIDA IMPbiological_process
GO:0008584Male gonad developmentIEPbiological_process
GO:0009267Cellular response to starvationIEPbiological_process
GO:0010942Positive regulation of cell deathIDAbiological_process
GO:0016488Farnesol catabolic processIDAbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0016655Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorIDAmolecular_function
GO:0018636Phenanthrene 9,10-monooxygenase activityIDAmolecular_function
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019371Cyclooxygenase pathwayTASbiological_process
GO:0030216Keratinocyte differentiationIEPbiological_process
GO:0034614Cellular response to reactive oxygen speciesIDAbiological_process
GO:0034694Response to prostaglandinIDAbiological_process
GO:0035410Dihydrotestosterone 17-beta-dehydrogenase activityIDAmolecular_function
GO:0036131Prostaglandin D2 11-ketoreductase activityIEAmolecular_function
GO:0042448Progesterone metabolic processIDAbiological_process
GO:0042574Retinal metabolic processIDAbiological_process
GO:0044259Multicellular organismal macromolecule metabolic processIEPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044597Daunorubicin metabolic processIMPbiological_process
GO:0044598Doxorubicin metabolic processIMPbiological_process
GO:0045550Geranylgeranyl reductase activityIDAmolecular_function
GO:0045703Ketoreductase activityIDAmolecular_function
GO:0047017Prostaglandin-F synthase activityIEAmolecular_function
GO:004702015-hydroxyprostaglandin-D dehydrogenase (NADP+) activityIDAmolecular_function
GO:0047023Androsterone dehydrogenase activityIDAmolecular_function
GO:0047035Testosterone dehydrogenase (NAD+) activityIEAmolecular_function
GO:0047045Testosterone 17-beta-dehydrogenase (NADP+) activityIEAmolecular_function
GO:0047086Ketosteroid monooxygenase activityIDAmolecular_function
GO:0047115Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityIEAmolecular_function
GO:0047718Indanol dehydrogenase activityIEAmolecular_function
GO:0047787Delta4-3-oxosteroid 5beta-reductase activityIDAmolecular_function
GO:0048385Regulation of retinoic acid receptor signaling pathwayIDAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0055114Oxidation-reduction processIDA TASbiological_process
GO:0061370Testosterone biosynthetic processIMPbiological_process
GO:0070293Renal absorptionNASbiological_process
GO:0071276Cellular response to cadmium ionIDAbiological_process
GO:0071277Cellular response to calcium ionIDAbiological_process
GO:0071379Cellular response to prostaglandin stimulusIDAbiological_process
GO:0071384Cellular response to corticosteroid stimulusIDAbiological_process
GO:0071395Cellular response to jasmonic acid stimulusIDAbiological_process
GO:1900053Negative regulation of retinoic acid biosynthetic processIDAbiological_process
GO:2000224Regulation of testosterone biosynthetic processIMPbiological_process
GO:2000353Positive regulation of endothelial cell apoptotic processIDAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06021090760.00720251890.53199439410.1695684258

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.0253214551
GSE13712_SHEARDown-4.5690182044
GSE13712_STATICDown-3.8427730005
GSE19018Down-0.4511949529
GSE19899_A1Up0.0750555434
GSE19899_A2Down-2.6227062931
PubMed_21979375_A1Down-0.2114468893
PubMed_21979375_A2Down-0.1416730141
GSE35957Up0.0960811100
GSE36640Down-0.1347592075
GSE54402Down-0.7610941380
GSE9593Up0.2110138114
GSE43922Up0.0138838903
GSE24585Up1.0775609743
GSE37065Up0.3916312830
GSE28863_A1Up0.5517572198
GSE28863_A2Up1.1576575896
GSE28863_A3Down-0.4477229896
GSE28863_A4Up0.0875356347
GSE48662Down-0.0451087464

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
BimatoprostDB00905 APRD00826 | DB06863
4-AndrostenedioneDB01536 EXPT00569 | DB07386
RutinDB01698 EXPT02824
(5e,13e)-9,15-Dihydroxy-11-Oxoprosta-5,13-Dien-1-OicacidDB02056 EXPT02562
Flufenamic AcidDB02266 EXPT01442
2'-Monophosphoadenosine 5'-DiphosphoriboseDB03461 EXPT02293
3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRANDB07700 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020887ProteomicsFunctional MTI (Weak)18668040
hsa-miR-98-5pMIMAT0000096MIRT027720MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.