HCSGD entry for HSD17B6
1. General information
| Official gene symbol | HSD17B6 |
|---|---|
| Entrez ID | 8630 |
| Gene full name | hydroxysteroid (17-beta) dehydrogenase 6 |
| Other gene symbols | HSE RODH SDR9C6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | TAS | molecular_function |
| GO:0004303 | Estradiol 17-beta-dehydrogenase activity | IEA | molecular_function |
| GO:0004745 | Retinol dehydrogenase activity | IEA | molecular_function |
| GO:0005622 | Intracellular | NAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0006702 | Androgen biosynthetic process | NAS | biological_process |
| GO:0006710 | Androgen catabolic process | TAS | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA NAS | molecular_function |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0047035 | Testosterone dehydrogenase (NAD+) activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6073530109 | 0.0069626838 | 0.9999902473 | 0.1666043636 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.7349021567 |
| GSE13712_SHEAR | Down | -0.2449386634 |
| GSE13712_STATIC | Down | -0.1069993449 |
| GSE19018 | Down | -1.2837116255 |
| GSE19899_A1 | Down | -0.1902166582 |
| GSE19899_A2 | Down | -1.8574054450 |
| PubMed_21979375_A1 | Down | -0.0014986635 |
| PubMed_21979375_A2 | Down | -1.3363205399 |
| GSE35957 | Down | -1.8352725599 |
| GSE36640 | Up | 2.1185559503 |
| GSE54402 | Down | -0.4833319926 |
| GSE9593 | Down | -0.1679396432 |
| GSE43922 | Down | -0.1216502401 |
| GSE24585 | Up | 0.6055092026 |
| GSE37065 | Down | -0.1859483208 |
| GSE28863_A1 | Up | 0.1490369959 |
| GSE28863_A2 | Up | 0.2400121676 |
| GSE28863_A3 | Up | 0.1471239902 |
| GSE28863_A4 | Up | 0.0470305306 |
| GSE48662 | Up | 0.0833746073 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023180 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 2211677 | 264, 12037-12045), we examined the regulation of a heat-inducible, heat shock element (HSE) sequence-specific binding protein in IMR-90 diploid fibroblasts |
| 2211677 | Using gel retardation assay, we showed that the HSE binding activity in extracts of IMR-90 cells was very dependent on heat shock of the cells; that the induction was transient with a maximal increase observed at 1 h of heat shock |
| 2211677 | By Scatchard analysis, we determined that this difference in HSE binding in young and old cells was not due to a change in the affinity of the binding, rather the level of the heat-inducible HSE-binding activity was different |
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