HCSGD entry for PDE8B

1. General information

Official gene symbolPDE8B
Entrez ID8622
Gene full namephosphodiesterase 8B
Other gene symbolsADSD PPNAD3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000156Phosphorelay response regulator activityIEAmolecular_function
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityNASmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005829CytosolTAScellular_component
GO:0006198CAMP catabolic processIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0009187Cyclic nucleotide metabolic processNASbiological_process
GO:0046676Negative regulation of insulin secretionIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73171992330.23490366630.99999024730.9330286748

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0679014510
GSE13712_SHEARUp0.0577567243
GSE13712_STATICUp0.0160086677
GSE19018Up0.0727372757
GSE19899_A1Up0.0498670710
GSE19899_A2Up0.0945769204
PubMed_21979375_A1Down-0.3019545672
PubMed_21979375_A2Down-0.1969058906
GSE35957Up0.0580777569
GSE36640Up0.0461473063
GSE54402Down-0.9586784255
GSE9593Down-1.1276123776
GSE43922Up0.0156482577
GSE24585Down-0.3998724020
GSE37065Up0.0250610309
GSE28863_A1Down-0.0103343372
GSE28863_A2Up0.6836007946
GSE28863_A3Up0.1726960557
GSE28863_A4Up0.0347397189
GSE48662Up0.0446101629

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

KetotifenDB00920 APRD01061

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018136MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.