HCSGD entry for TNFSF11

1. General information

Official gene symbolTNFSF11
Entrez ID8600
Gene full nametumor necrosis factor (ligand) superfamily, member 11
Other gene symbolsCD254 ODF OPGL OPTB2 RANKL TRANCE hRANKL2 sOdf
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0002158Osteoclast proliferationIEAbiological_process
GO:0002548Monocyte chemotaxisIDAbiological_process
GO:0005125Cytokine activityIDA NASmolecular_function
GO:0005164Tumor necrosis factor receptor bindingNASmolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006955Immune responseNASbiological_process
GO:0007257Activation of JUN kinase activityIEAbiological_process
GO:0009887Organ morphogenesisIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0030316Osteoclast differentiationIDA ISS NASbiological_process
GO:0032813Tumor necrosis factor receptor superfamily bindingICmolecular_function
GO:0033209Tumor necrosis factor-mediated signaling pathwayISSbiological_process
GO:0033598Mammary gland epithelial cell proliferationIEAbiological_process
GO:0034112Positive regulation of homotypic cell-cell adhesionIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0045453Bone resorptionIEAbiological_process
GO:0045672Positive regulation of osteoclast differentiationIDAbiological_process
GO:0045780Positive regulation of bone resorptionIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIEAbiological_process
GO:0050870Positive regulation of T cell activationIDAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityISSbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051466Positive regulation of corticotropin-releasing hormone secretionISSbiological_process
GO:0051897Positive regulation of protein kinase B signalingIEAbiological_process
GO:0055074Calcium ion homeostasisIEAbiological_process
GO:0060749Mammary gland alveolus developmentIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0071812Positive regulation of fever generation by positive regulation of prostaglandin secretionISSbiological_process
GO:0071847TNFSF11-mediated signaling pathwayIDAbiological_process
GO:0071848Positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingIDAbiological_process
GO:1902533Positive regulation of intracellular signal transductionIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29457078380.37168467760.99419979511.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0387876401
GSE13712_SHEARUp0.0037101679
GSE13712_STATICUp0.5597430200
GSE19018Up0.2102176156
GSE19899_A1Up0.0865021429
GSE19899_A2Up0.2514648199
PubMed_21979375_A1Up0.1156240315
PubMed_21979375_A2Up0.1380710232
GSE35957Down-0.3669563197
GSE36640Up0.0215207018
GSE54402Up0.7635498444
GSE9593Down-2.8644630731
GSE43922Up0.0275385580
GSE24585Down-0.0217608903
GSE37065Down-0.0071281101
GSE28863_A1Down-0.2027186097
GSE28863_A2Down-0.1269766785
GSE28863_A3Up0.2102618319
GSE28863_A4Up0.0409142697
GSE48662Up0.0121314044

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

LenalidomideDB00480 APRD01303
DenosumabDB06643 -
ThiocolchicosideDB11582 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-18a-5pMIMAT0000072MIRT004387Microarray//Northern blot//Luciferase reporter assayFunctional MTI16331254
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27188231Morc3(mut +/-) mice displayed reduced osteoclast numbers and surface per bone surface as well as osteocyte numbers, concomitant with altered gene expressions such as Rankl/Opg and Sost in ex vivo long bones
23281008This leads to enhanced secretion of inflammatory cytokines known to drive osteoclastogenesis, such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and receptor activator of NF-kappaB ligand (RANKL), and thereby induces an inflammatory bone microenvironment favoring osteoclastogenesis
Entries Per Page
Displaying Page of