HCSGD entry for MKNK1
1. General information
| Official gene symbol | MKNK1 |
|---|---|
| Entrez ID | 8569 |
| Gene full name | MAP kinase interacting serine/threonine kinase 1 |
| Other gene symbols | MNK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009651 | Response to salt stress | IEA | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2616535998 | 0.9144718590 | 0.9548629280 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0714256802 |
| GSE13712_SHEAR | Up | 0.1587790049 |
| GSE13712_STATIC | Up | 0.1167294485 |
| GSE19018 | Down | -0.0836371855 |
| GSE19899_A1 | Down | -0.0175118170 |
| GSE19899_A2 | Up | 0.6565250267 |
| PubMed_21979375_A1 | Up | 0.0446500799 |
| PubMed_21979375_A2 | Up | 0.2403366785 |
| GSE35957 | Up | 0.0128817214 |
| GSE36640 | Up | 0.5454084944 |
| GSE54402 | Up | 0.0027938185 |
| GSE9593 | Down | -0.2284283673 |
| GSE43922 | Down | -0.0339906522 |
| GSE24585 | Up | 0.3666273237 |
| GSE37065 | Down | -0.0324998136 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0017618574 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029104 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22227431 | MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1 |
| 22227431 | We have demonstrated that pharmacological inhibition of MNK1 by CGP 57380 decreased the phosphorylation levels of hnRNP A1 in young and senescent fibroblast cells and blocked the cytoplasmic accumulation of hnRNP A1 in senescent cells |
| 22227431 | In addition, MNK1 formed a complex with hnRNP A1 in vivo |
| 22227431 | The expression levels of MNK1, phospho-MNK1, and phospho-eIF4E proteins were found to be elevated in senescent cells |
| 22227431 | These data suggest that MNK1 regulates the phosphorylation and the subcellular distribution of hnRNP A1 and that MNK1 may play a role in the induction of senescence |
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