HCSGD entry for YARS
1. General information
| Official gene symbol | YARS |
|---|---|
| Entrez ID | 8565 |
| Gene full name | tyrosyl-tRNA synthetase |
| Other gene symbols | CMTDIC TYRRS YRS YTS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IEA | molecular_function |
| GO:0004831 | Tyrosine-tRNA ligase activity | TAS | molecular_function |
| GO:0004871 | Signal transducer activity | NAS | molecular_function |
| GO:0005153 | Interleukin-8 receptor binding | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006437 | Tyrosyl-tRNA aminoacylation | IEA | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3580837506 | 0.4558876145 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1891105393 |
| GSE13712_SHEAR | Up | 0.3894118011 |
| GSE13712_STATIC | Up | 0.1624369297 |
| GSE19018 | Up | 0.4544162360 |
| GSE19899_A1 | Up | 0.1535407903 |
| GSE19899_A2 | Down | -0.1015022968 |
| PubMed_21979375_A1 | Up | 0.2469818324 |
| PubMed_21979375_A2 | Down | -0.0480447232 |
| GSE35957 | Down | -0.3959395374 |
| GSE36640 | Down | -0.2837004547 |
| GSE54402 | Down | -0.1422462545 |
| GSE9593 | Down | -0.1150335559 |
| GSE43922 | Up | 0.2170884478 |
| GSE24585 | Up | 0.1401637421 |
| GSE37065 | Down | -0.4386764724 |
| GSE28863_A1 | Up | 0.2877505271 |
| GSE28863_A2 | Up | 0.1214905561 |
| GSE28863_A3 | Down | -0.0957171132 |
| GSE28863_A4 | Down | -0.2562116372 |
| GSE48662 | Up | 0.1482862694 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Beta-(2-Naphthyl)-Alanine | DB01766 | EXPT02291 |
| Tyrosinal | DB03978 | EXPT03134 |
| N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE | DB07205 | - |
| PARA-(BENZOYL)-PHENYLALANINE | DB08371 | - |
| 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE | DB08617 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020751 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037152 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038166 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041463 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045031 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
