HCSGD entry for THOC5
1. General information
| Official gene symbol | THOC5 |
|---|---|
| Entrez ID | 8563 |
| Gene full name | THO complex 5 |
| Other gene symbols | C22orf19 Fmip PK1.3 fSAP79 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000346 | Transcription export complex | IDA | cellular_component |
| GO:0000347 | THO complex | IDA | cellular_component |
| GO:0000445 | THO complex part of transcription export complex | IDA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0006406 | MRNA export from nucleus | IDA | biological_process |
| GO:0008380 | RNA splicing | IEA | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0030224 | Monocyte differentiation | IDA | biological_process |
| GO:0032786 | Positive regulation of DNA-templated transcription, elongation | IMP | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0045650 | Negative regulation of macrophage differentiation | IEA | biological_process |
| GO:0046784 | Viral mRNA export from host cell nucleus | IDA | biological_process |
| GO:0060215 | Primitive hemopoiesis | IEA ISS | biological_process |
| GO:2000002 | Negative regulation of DNA damage checkpoint | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0476656966 | 0.9671120512 | 0.4823515175 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2943615628 |
| GSE13712_SHEAR | Down | -0.0399472432 |
| GSE13712_STATIC | Up | 0.0169666480 |
| GSE19018 | Down | -0.0773647635 |
| GSE19899_A1 | Up | 0.0991779199 |
| GSE19899_A2 | Up | 0.3614799170 |
| PubMed_21979375_A1 | Up | 0.8227890430 |
| PubMed_21979375_A2 | Up | 0.7167930415 |
| GSE35957 | Down | -0.0143656138 |
| GSE36640 | Down | -0.0800490247 |
| GSE54402 | Up | 0.7546921293 |
| GSE9593 | Down | -0.0399218337 |
| GSE43922 | Up | 0.4761027502 |
| GSE24585 | Up | 0.0522032692 |
| GSE37065 | Down | -0.0663414792 |
| GSE28863_A1 | Up | 0.4091224226 |
| GSE28863_A2 | Up | 0.2495853108 |
| GSE28863_A3 | Down | -0.2568552788 |
| GSE28863_A4 | Down | -0.0464288479 |
| GSE48662 | Up | 0.2087714027 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027661 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039858 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044988 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-3p | MIMAT0000088 | MIRT049915 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051410 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052279 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
