HCSGD entry for DEGS1
1. General information
| Official gene symbol | DEGS1 |
|---|---|
| Entrez ID | 8560 |
| Gene full name | delta(4)-desaturase, sphingolipid 1 |
| Other gene symbols | DEGS DEGS-1 DES1 Des-1 FADS7 MLD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0006636 | Unsaturated fatty acid biosynthetic process | TAS | biological_process |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | molecular_function |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7047234869 | 0.1699450477 | 0.9999902473 | 0.7976325963 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2192143748 |
| GSE13712_SHEAR | Up | 0.2940590259 |
| GSE13712_STATIC | Up | 0.1603323702 |
| GSE19018 | Down | -0.6057717783 |
| GSE19899_A1 | Down | -0.2379140997 |
| GSE19899_A2 | Up | 0.0412095784 |
| PubMed_21979375_A1 | Down | -0.1625487311 |
| PubMed_21979375_A2 | Down | -0.3806197107 |
| GSE35957 | Down | -0.0149928797 |
| GSE36640 | Up | 0.7252560715 |
| GSE54402 | Down | -0.3769287466 |
| GSE9593 | Up | 0.4587028817 |
| GSE43922 | Up | 0.0577234013 |
| GSE24585 | Up | 0.3109145556 |
| GSE37065 | Up | 0.2025521948 |
| GSE28863_A1 | Down | -0.2191906773 |
| GSE28863_A2 | Up | 0.0532197330 |
| GSE28863_A3 | Down | -0.2708815819 |
| GSE28863_A4 | Down | -0.2693617134 |
| GSE48662 | Down | -0.0821989694 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020768 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024553 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026493 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047375 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT050636 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052511 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24157427 | The DEGs (differentially expressed genes) in D |
| 24157427 | In the intersection of short-term and long-term exposure, a series of DEGs were related to apoptosis, aging, immunological stress and reproduction |
| 19471889 | Using total RNAs from 6 and 24-month old rat tissues, differential display reverse transcriptase polymerase chain reaction (DD RT-PCR) were performed and 12 differentially expressed genes (DEGs) which were down- or up-regulated in aged rat tissues were found |
| 19471889 | Among these DEGs, the level of prosaposin mRNA was elevated of in senescent human dermal fibroblast (HDF) and human umbilical vein endothelial cells (HUVECs) |
| 18452712 | Using an intersection analysis of 3892 differentially expressed genes (DEGs) out of 27,171 total genes analyzed, we identified 338 senescence-related DEGs |
| 18258400 | Using 120 ACPs, we identified 31 differentially expressed genes (DEGs) |
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