HCSGD entry for CDC14B
1. General information
| Official gene symbol | CDC14B |
|---|---|
| Entrez ID | 8555 |
| Gene full name | cell division cycle 14B |
| Other gene symbols | CDC14B3 Cdc14B1 Cdc14B2 hCDC14B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004722 | Protein serine/threonine phosphatase activity | IDA | molecular_function |
| GO:0004725 | Protein tyrosine phosphatase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006470 | Protein dephosphorylation | IMP NAS | biological_process |
| GO:0008138 | Protein tyrosine/serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0031572 | G2 DNA damage checkpoint | IDA | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | IDA | biological_process |
| GO:0051488 | Activation of anaphase-promoting complex activity | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6360802857 | 0.0503831085 | 0.9999902473 | 0.4204609385 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0799916056 |
| GSE13712_SHEAR | Down | -0.1741775121 |
| GSE13712_STATIC | Up | 0.1164546650 |
| GSE19018 | Down | -0.4320206272 |
| GSE19899_A1 | Down | -0.5145987540 |
| GSE19899_A2 | Down | -0.4862213386 |
| PubMed_21979375_A1 | Down | -0.6363735483 |
| PubMed_21979375_A2 | Down | -0.5587906451 |
| GSE35957 | Up | 0.4244513832 |
| GSE36640 | Up | 0.3050078467 |
| GSE54402 | Down | -0.4990200389 |
| GSE9593 | Up | 0.3324096242 |
| GSE43922 | Down | -1.0136566734 |
| GSE24585 | Up | 0.3210261113 |
| GSE37065 | Down | -0.0297629194 |
| GSE28863_A1 | Up | 0.7284523727 |
| GSE28863_A2 | Down | -0.0626338580 |
| GSE28863_A3 | Down | -0.1676790068 |
| GSE28863_A4 | Up | 0.0133979710 |
| GSE48662 | Down | -0.0108945821 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000826 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000827 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002563 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002563 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029462 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26029164 | Furthermore, we investigated the correlated expression patterns of Cdc14B, ESCO1, KPNA5, MAP3K3, and CSIG during cell cycle and senescence progression, which imply the important pathways CSIG regulating cell cycle and senescence |
| 26029164 | The mechanism study showed that CSIG modulated the mRNA half-life of Cdc14B, CASP7, and CREBL2 |
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