HCSGD entry for BHLHE40

1. General information

Official gene symbolBHLHE40
Entrez ID8553
Gene full namebasic helix-loop-helix family, member e40
Other gene symbolsBHLHB2 DEC1 HLHB2 SHARP-2 STRA13 Stra14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingISSmolecular_function
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityNASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0032922Circadian regulation of gene expressionIDAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043153Entrainment of circadian clock by photoperiodISSbiological_process
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043426MRF bindingISSmolecular_function
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0070888E-box bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00392418220.23419014480.16822214980.9319804657

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7225722999
GSE13712_SHEARUp0.4166781133
GSE13712_STATICUp1.4967572395
GSE19018Up0.4522075906
GSE19899_A1Up1.4662787849
GSE19899_A2Up1.0467554403
PubMed_21979375_A1Up1.5093672431
PubMed_21979375_A2Up1.6357462036
GSE35957Down-1.5847192047
GSE36640Down-0.4489470415
GSE54402Down-0.3957047442
GSE9593Up0.7663277091
GSE43922Up1.2899387568
GSE24585Down-0.2925716473
GSE37065Up0.4476420795
GSE28863_A1Down-0.4061805662
GSE28863_A2Up0.4290432262
GSE28863_A3Down-0.2850841992
GSE28863_A4Down-0.2274910803
GSE48662Up0.2271946482

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018020MicroarrayFunctional MTI (Weak)18185580
hsa-miR-941MIMAT0004984MIRT036578CLASHFunctional MTI (Weak)23622248
hsa-miR-454-3pMIMAT0003885MIRT039240CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25355277MSCs were treated with high glucose (HG) in order to induce senescence, which was markedly attenuated by pre-treatment with isosorbide dinitrate (ISDN), a commonly used nitrate, as indicated by senescence-associated galactosidase (SA-beta-gal) activity, p21 expression, as well as by the mRNA levels of DNA methyltransferase 1 (DNMT1) and differentiated embryo chondrocyte expressed gene 1 (DEC1), which are senescence-related biomarkers
22844531Human differentiated embryo chondrocyte expressed gene 1 (Dec1) is an important transcription factor that related to senescence
21765040CADPE induces cell senescence and morphology changes by increasing cellular size and cytoplasmic granularity, enhancing senescence-associated beta-galactosidase activity and differentiated embryo-chondrocyte expressed gene 1 expression, and blocking cell-cycle arrest in the G(1) phase
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