HCSGD entry for MAPKAPK5
1. General information
| Official gene symbol | MAPKAPK5 |
|---|---|
| Entrez ID | 8550 |
| Gene full name | mitogen-activated protein kinase-activated protein kinase 5 |
| Other gene symbols | MAPKAP-K5 MK-5 MK5 PRAK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0002039 | P53 binding | IDA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004708 | MAP kinase kinase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006417 | Regulation of translation | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | IDA | biological_process |
| GO:0032007 | Negative regulation of TOR signaling | ISS | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0051019 | Mitogen-activated protein kinase binding | IEA | molecular_function |
| GO:0090400 | Stress-induced premature senescence | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3809614452 | 0.6540678394 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2915612440 |
| GSE13712_SHEAR | Down | -0.0189971704 |
| GSE13712_STATIC | Up | 0.0431417616 |
| GSE19018 | Down | -0.1891168647 |
| GSE19899_A1 | Up | 0.0413252547 |
| GSE19899_A2 | Up | 0.1438068789 |
| PubMed_21979375_A1 | Up | 0.4639405560 |
| PubMed_21979375_A2 | Up | 0.2870517450 |
| GSE35957 | Down | -0.1598014624 |
| GSE36640 | Down | -0.2623869541 |
| GSE54402 | Up | 0.3057534366 |
| GSE9593 | Down | -0.0844096067 |
| GSE43922 | Down | -0.0114131217 |
| GSE24585 | Down | -0.1040547521 |
| GSE37065 | Up | 0.0590839296 |
| GSE28863_A1 | Up | 0.2150998624 |
| GSE28863_A2 | Up | 0.1878917125 |
| GSE28863_A3 | Down | -0.4289809689 |
| GSE28863_A4 | Up | 0.1250501666 |
| GSE48662 | Down | -0.3480300822 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT039763 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20647589 | 2000442) reported that the human kinase p38-regulated/activated protein kinase (PRAK) was phosphorylated on residue Ser(93) in senescent cells |
| 20647589 | We have been unable to detect phosphorylation at this site with the antibody that they used, and the commercial supplier of this antibody has discontinued its availability, which casts doubt on whether this residue of PRAK is phosphorylated |
| 17254959 | They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53 |
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