HCSGD entry for TSLP
1. General information
| Official gene symbol | TSLP |
|---|---|
| Entrez ID | 85480 |
| Gene full name | thymic stromal lymphopoietin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0013596064 | 0.3087872915 | 0.0995980556 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.1147493077 |
| GSE13712_SHEAR | Up | 0.5926407940 |
| GSE13712_STATIC | Up | 1.0568489610 |
| GSE19018 | Down | -1.6813621771 |
| GSE19899_A1 | Down | -0.2635538946 |
| GSE19899_A2 | Down | -0.0016719659 |
| PubMed_21979375_A1 | Up | 3.5394186773 |
| PubMed_21979375_A2 | Up | 1.8062892178 |
| GSE35957 | Down | -1.8569571729 |
| GSE36640 | Up | 1.1198027240 |
| GSE54402 | Down | -1.0880785435 |
| GSE9593 | Up | 2.4959556106 |
| GSE43922 | Up | 0.3578391084 |
| GSE24585 | Up | 0.7736184171 |
| GSE37065 | Up | 0.6959043271 |
| GSE28863_A1 | Down | -0.1199392356 |
| GSE28863_A2 | Up | 0.1659757359 |
| GSE28863_A3 | Up | 0.1902231331 |
| GSE28863_A4 | Down | -0.0726376155 |
| GSE48662 | Up | 0.0102495898 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017769 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24167583 | Thymic stromal lymphopoietin (TSLP), a vital cytokine, plays a critical role in orchestrating, perpetuating and amplifying the inflammatory response in asthma |
| 24167583 | TSLP is also a critical factor in airway remodeling in asthma |
| 24167583 | CONCLUSION: TSLP stimulation can induce cellular senescence during airway remodeling in asthma |
| 20038483 | IL-7 protects both B and T lymphocytes, but IL-2, IL-10, keratinocyte growth factor, thymic stromal lymphopoietin, as well as leptin and growth hormone also have a stimulatory effect on thymopoiesis |
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