HCSGD entry for KNDC1

1. General information

Official gene symbolKNDC1
Entrez ID85442
Gene full namekinase non-catalytic C-lobe domain (KIND) containing 1
Other gene symbolsC10orf23 RASGEF2 bB439H18.3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0003674Molecular_functionNDmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005088Ras guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005622IntracellularIEAcellular_component
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0008150Biological_processNDbiological_process
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0021707Cerebellar granule cell differentiationIEAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0032045Guanyl-nucleotide exchange factor complexIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0048814Regulation of dendrite morphogenesisIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85719399340.70240833180.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0474759143
GSE13712_SHEARDown-0.0216770611
GSE13712_STATICDown-0.0270333148
GSE19018Up0.1348327724
GSE19899_A1Down-0.0981672172
GSE19899_A2Down-0.0074812015
PubMed_21979375_A1Down-0.0707774652
PubMed_21979375_A2Down-0.0980512398
GSE35957Up0.1638760804
GSE36640Up0.1868280420
GSE54402Down-0.1974111234
GSE9593Up0.0214594734
GSE43922Up0.0426636946
GSE24585Down-0.1792950430
GSE37065Down-0.0295225086
GSE28863_A1Down-0.0848131600
GSE28863_A2Down-0.0193775479
GSE28863_A3Up0.2917837516
GSE28863_A4Up0.0842341105
GSE48662Down-0.0151350814

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24788352KNDC1 knockdown protects human umbilical vein endothelial cells from senescence
24788352The present study investigated the impact of KNDC1 knockdown on human endothelial cell senescence and the mechanisms underlying this effect
24788352In the HUVECs, a senescence-like phenotypes developed with increasing passage number in vitro, which were associated with a progressive increase in the transcription and expression of KNDC1
24788352KNDC1 knockdown promoted cell proliferation and partially reversed cellular senescence and cell cycle arrest in the G0/G1 phase in aging HUVECs
24788352Investigations into the mechanism underlying this effect demonstrated that KNDC1 knockdown promoted HUVEC proliferation via the extracellular signal-regulated kinase signaling pathway and delayed HUVEC senescence by inhibiting the p53-p21-p16 transduction cascade
24788352In conclusion, KNDC1 knockdown delayed endothelial cell senescence and promoted HUVEC activity and function
24788352These results demonstrated that KNDC1 may be a novel therapeutic target for the development of agents to extend human life
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