HCSGD entry for PIR
1. General information
| Official gene symbol | PIR |
|---|---|
| Entrez ID | 8544 |
| Gene full name | pirin (iron-binding nuclear protein) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003712 | Transcription cofactor activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008127 | Quercetin 2,3-dioxygenase activity | IDA | molecular_function |
| GO:0030224 | Monocyte differentiation | IMP | biological_process |
| GO:0046872 | Metal ion binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8215530109 | 0.0054707306 | 0.9999902473 | 0.1495908619 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1348184766 |
| GSE13712_SHEAR | Down | -0.2004370606 |
| GSE13712_STATIC | Down | -0.0740360117 |
| GSE19018 | Down | -0.4702679525 |
| GSE19899_A1 | Down | -1.1119152234 |
| GSE19899_A2 | Down | -2.9411518865 |
| PubMed_21979375_A1 | Down | -2.5608767307 |
| PubMed_21979375_A2 | Down | -3.4794993009 |
| GSE35957 | Down | -1.5079082123 |
| GSE36640 | Up | 1.8405520996 |
| GSE54402 | Down | -0.0580512948 |
| GSE9593 | Down | -0.2496595496 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.2687582443 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023859 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21514450 | Pirin (PIR) is a highly conserved nuclear protein that likely functions as a transcriptional regulator whose expression levels are altered in different types of tumors |
| 21514450 | We analyzed the expression pattern of PIR in adult human tissues and found that it is expressed in melanocytes and has a complex pattern of regulation in nevi and melanoma: it is rarely detected in mature nevi, but is expressed at high levels in a subset of melanomas |
| 21514450 | Loss of function and overexpression experiments in normal and transformed melanocytic cells revealed that PIR is involved in the negative control of cellular senescence and that its expression is necessary to overcome the senescence barrier |
| 21514450 | Our results suggest that PIR may have a relevant role in melanoma progression |
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