HCSGD entry for MYLK2

1. General information

Official gene symbolMYLK2
Entrez ID85366
Gene full namemyosin light chain kinase 2
Other gene symbolsKMLC MLCK MLCK2 skMLCK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004683Calmodulin-dependent protein kinase activityISSmolecular_function
GO:0004687Myosin light chain kinase activityIDA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIC ISSmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006941Striated muscle contractionIDAbiological_process
GO:0007274Neuromuscular synaptic transmissionIEAbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0014816Satellite cell differentiationIEAbiological_process
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0030017SarcomereICcellular_component
GO:0032971Regulation of muscle filament slidingIDAbiological_process
GO:0035914Skeletal muscle cell differentiationIDAbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0055008Cardiac muscle tissue morphogenesisIMPbiological_process
GO:0060048Cardiac muscle contractionICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52292515100.85351457390.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0550166835
GSE13712_SHEARDown-0.0656136531
GSE13712_STATICDown-0.0192632556
GSE19018Up0.1086243912
GSE19899_A1Down-0.0433117795
GSE19899_A2Up0.1460951170
PubMed_21979375_A1Up0.4881249743
PubMed_21979375_A2Up0.1268988010
GSE35957Up0.0708353411
GSE36640Down-0.1277890180
GSE54402Up0.0234967352
GSE9593Down-0.0328662703
GSE43922Up0.0289148056
GSE24585Down-0.1204537170
GSE37065Up0.0612190849
GSE28863_A1Down-0.0764865856
GSE28863_A2Down-0.0748441713
GSE28863_A3Up0.2922764436
GSE28863_A4Up0.1024817083
GSE48662Up0.1854738614

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.