HCSGD entry for SHANK3

1. General information

Official gene symbol	SHANK3
Entrez ID	85358
Gene full name	SH3 and multiple ankyrin repeat domains 3
Other gene symbols	DEL22q13.3 PROSAP2 PSAP2 SCZD15 SPANK-2
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000165	MAPK cascade	IEA ISS	biological_process
GO:0001838	Embryonic epithelial tube formation	IEA	biological_process
GO:0005515	Protein binding	IPI	molecular_function
GO:0005737	Cytoplasm	IEA	cellular_component
GO:0005886	Plasma membrane	ISS	cellular_component
GO:0007416	Synapse assembly	ISS	biological_process
GO:0007612	Learning	IEA ISS	biological_process
GO:0007613	Memory	IEA ISS	biological_process
GO:0008022	Protein C-terminus binding	IEA ISS	molecular_function
GO:0008270	Zinc ion binding	IEA ISS	molecular_function
GO:0017124	SH3 domain binding	IEA ISS	molecular_function
GO:0021773	Striatal medium spiny neuron differentiation	IEA ISS	biological_process
GO:0030054	Cell junction	IEA	cellular_component
GO:0030160	GKAP/Homer scaffold activity	IEA ISS	molecular_function
GO:0032232	Negative regulation of actin filament bundle assembly	IEA ISS	biological_process
GO:0035176	Social behavior	IEA ISS	biological_process
GO:0035255	Ionotropic glutamate receptor binding	IEA ISS	molecular_function
GO:0035641	Locomotory exploration behavior	IEA	biological_process
GO:0042802	Identical protein binding	IEA ISS	molecular_function
GO:0043005	Neuron projection	ISS	cellular_component
GO:0043621	Protein self-association	IEA	molecular_function
GO:0044309	Neuron spine	ISS	cellular_component
GO:0045211	Postsynaptic membrane	IEA	cellular_component
GO:0045794	Negative regulation of cell volume	IEA ISS	biological_process
GO:0048170	Positive regulation of long-term neuronal synaptic plasticity	IEA ISS	biological_process
GO:0048854	Brain morphogenesis	IEA ISS	biological_process
GO:0050885	Neuromuscular process controlling balance	IEA	biological_process
GO:0051259	Protein oligomerization	IEA	biological_process
GO:0051835	Positive regulation of synapse structural plasticity	IEA ISS	biological_process
GO:0051968	Positive regulation of synaptic transmission, glutamatergic	IEA ISS	biological_process
GO:0060170	Ciliary membrane	IEA ISS	cellular_component
GO:0060997	Dendritic spine morphogenesis	IEA ISS	biological_process
GO:0060999	Positive regulation of dendritic spine development	IEA ISS	biological_process
GO:0061001	Regulation of dendritic spine morphogenesis	IEA ISS	biological_process
GO:0071625	Vocalization behavior	IEA ISS	biological_process
GO:0097107	Postsynaptic density assembly	IEA ISS	biological_process
GO:0097110	Scaffold protein binding	IEA ISS	molecular_function
GO:0097113	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering	IEA ISS	biological_process
GO:0097114	N-methyl-D-aspartate receptor clustering	IEA ISS	biological_process
GO:0097117	Guanylate kinase-associated protein clustering	IEA ISS	biological_process
GO:0097481	Neuronal postsynaptic density	IEA ISS	cellular_component
GO:1900271	Regulation of long-term synaptic potentiation	IEA ISS	biological_process
GO:1900451	Positive regulation of glutamate receptor signaling pathway	IEA ISS	biological_process
GO:1900452	Regulation of long term synaptic depression	IEA ISS	biological_process
GO:2000463	Positive regulation of excitatory postsynaptic membrane potential	IEA ISS	biological_process
GO:2000821	Regulation of grooming behavior	IEA	biological_process
GO:2000822	Regulation of behavioral fear response	IEA	biological_process
GO:2000969	Positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	IEA ISS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.1363564302	0.9396887010	0.7450168637	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0351601933
GSE13712_SHEAR	Down	-0.2709001382
GSE13712_STATIC	Up	0.0417770501
GSE19018	Up	0.0551076822
GSE19899_A1	Down	-0.0627221185
GSE19899_A2	Up	0.3083284621
PubMed_21979375_A1	Down	-0.1036291335
PubMed_21979375_A2	Up	0.7394691269
GSE35957	Down	-0.0839920414
GSE36640	Up	0.4344035222
GSE54402	Up	0.4634486004
GSE9593	Up	0.3519838146
GSE43922	Up	0.0795435053
GSE24585	Down	-0.2196184933
GSE37065	Up	0.0509197414
GSE28863_A1	Down	-0.0137024898
GSE28863_A2	Up	0.0098486295
GSE28863_A3	Up	0.3995136949
GSE28863_A4	Up	0.1226502111
GSE48662	Up	0.1316899215

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results