HCSGD entry for HAT1
1. General information
| Official gene symbol | HAT1 |
|---|---|
| Entrez ID | 8520 |
| Gene full name | histone acetyltransferase 1 |
| Other gene symbols | KAT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004402 | Histone acetyltransferase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006323 | DNA packaging | TAS | biological_process |
| GO:0006348 | Chromatin silencing at telomere | IEA | biological_process |
| GO:0006475 | Internal protein amino acid acetylation | TAS | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8748085331 | 0.0349253790 | 0.9999902473 | 0.3534241644 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0059211484 |
| GSE13712_SHEAR | Down | -0.0863886447 |
| GSE13712_STATIC | Down | -0.0175775895 |
| GSE19018 | Down | -0.4615808461 |
| GSE19899_A1 | Down | -0.0103012646 |
| GSE19899_A2 | Down | -1.1831444655 |
| PubMed_21979375_A1 | Up | 0.1110644631 |
| PubMed_21979375_A2 | Down | -0.7249510961 |
| GSE35957 | Down | -0.5682447352 |
| GSE36640 | Down | -0.7783542705 |
| GSE54402 | Up | 0.1230244009 |
| GSE9593 | Down | -0.7285004259 |
| GSE43922 | Down | -0.0605389509 |
| GSE24585 | Up | 0.3630677656 |
| GSE37065 | Up | 0.1216642710 |
| GSE28863_A1 | Up | 0.0453780845 |
| GSE28863_A2 | Up | 0.7634401495 |
| GSE28863_A3 | Down | -0.3751650315 |
| GSE28863_A4 | Down | -0.2207273797 |
| GSE48662 | Down | -0.5019731983 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-32-5p | MIMAT0000090 | MIRT028253 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20148353 | In this report, it is shown for the first time that human Hat1 has two isoforms |
| 20148353 | Immunohistochemical analyses revealed that the bulk of Hat1 is confined to the nucleus, with much lesser amounts in the cytoplasm |
| 20148353 | Cells undergoing mitotic division have an elevated amount of Hat1 compared to those that are non-mitotic |
| 20148353 | Senescent cells, however, exhibit a higher concentration of Hat1 in the cytoplasm compare to proliferating cells and the amount of Hat1 in the nucleus decreases with the progression of senescence |
| 20148353 | NHKs exposed to hydrogen peroxide (H(2)O(2)) or to a beam of high mass and energy ion particles displayed bright nuclear staining for Hat1, a phenotype that was not observed in NHKs exposed to gamma-rays |
| 20148353 | Our observations clearly implicate Hat1 in the cellular response assuring the survival of the treated cells |
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