HCSGD entry for IKBKAP
1. General information
| Official gene symbol | IKBKAP |
|---|---|
| Entrez ID | 8518 |
| Gene full name | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
| Other gene symbols | DYS ELP1 FD IKAP IKI3 TOT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0004871 | Signal transducer activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA TAS | biological_process |
| GO:0006368 | Transcription elongation from RNA polymerase II promoter | IDA | biological_process |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008023 | Transcription elongation factor complex | IDA | cellular_component |
| GO:0008607 | Phosphorylase kinase regulator activity | IDA | molecular_function |
| GO:0016591 | DNA-directed RNA polymerase II, holoenzyme | IDA | cellular_component |
| GO:0030335 | Positive regulation of cell migration | IEA ISS | biological_process |
| GO:0033588 | Elongator holoenzyme complex | IDA | cellular_component |
| GO:0042325 | Regulation of phosphorylation | IDA TAS | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IDA TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | IDA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4439373618 | 0.5106831085 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0164205348 |
| GSE13712_SHEAR | Down | -0.1619717335 |
| GSE13712_STATIC | Up | 0.0746169006 |
| GSE19018 | Down | -0.0071914177 |
| GSE19899_A1 | Down | -0.1583583419 |
| GSE19899_A2 | Down | -0.0289478794 |
| PubMed_21979375_A1 | Down | -0.2284122469 |
| PubMed_21979375_A2 | Up | 0.1358657118 |
| GSE35957 | Down | -0.1856637467 |
| GSE36640 | Up | 0.2117131995 |
| GSE54402 | Up | 0.0994895727 |
| GSE9593 | Up | 0.0131835312 |
| GSE43922 | Up | 0.0016346964 |
| GSE24585 | Down | -0.0397133076 |
| GSE37065 | Down | -0.0657267872 |
| GSE28863_A1 | Up | 0.1554786641 |
| GSE28863_A2 | Up | 0.5863645998 |
| GSE28863_A3 | Down | -0.7355998632 |
| GSE28863_A4 | Up | 0.2576807690 |
| GSE48662 | Up | 0.4629610880 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023692 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029432 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038420 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038854 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049662 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT050380 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
