HCSGD entry for IKBKG

1. General information

Official gene symbolIKBKG
Entrez ID8517
Gene full nameinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Other gene symbolsAMCBX1 FIP-3 FIP3 Fip3p IKK-gamma IP IP1 IP2 IPD2 NEMO ZC2HC9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0006955Immune responseTASbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityIEAbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0008385IkappaB kinase complexTAScellular_component
GO:0009615Response to virusTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIDA IEAmolecular_function
GO:0050852T cell receptor signaling pathwayNAS TASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDA TASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24607856080.84391137110.93497387431.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1303625580
GSE13712_SHEARUp0.5397929126
GSE13712_STATICUp0.2860939518
GSE19018Down-0.0665462696
GSE19899_A1Down-0.4000112502
GSE19899_A2Up0.1252086838
PubMed_21979375_A1Up0.6528424724
PubMed_21979375_A2Up0.1410857556
GSE35957Up0.0875728367
GSE36640Up0.1600074022
GSE54402Down-0.1124944158
GSE9593Up0.1413849257
GSE43922Down-0.1080255932
GSE24585Down-0.2154333428
GSE37065Down-0.1730752406
GSE28863_A1Up0.0462284591
GSE28863_A2Down-0.0523621190
GSE28863_A3Up0.2034865930
GSE28863_A4Up0.2103053238
GSE48662Up0.1714319778

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AGRO100DB04998 -
MPC-7869DB05289 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-15a-5pMIMAT0000068MIRT051313CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25536232NEMO modulates radiation-induced endothelial senescence of human umbilical veins through NF-kappaB signal pathway
25536232PS1145 is a novel, highly specific small-molecule inhibitor of nuclear factor kappa B essential modulator (NEMO)
25536232Taken together, these findings indicate that the angiogenic capacity of radiation-induced senescence-like HUVECs decreased, and that irradiation caused vascular endothelial cells to gain a senescence-like phenotype through the DSB/NEMO/NF-kappaB signal pathway
25536232The data suggests that NEMO may be a critical switch that regulates cellular senescence and apoptosis caused by exposure to radiation, and provides new clues for the clinical potential of the combination of radiotherapy and angiogenesis inhibitors
25255445The classical (or canonical) pathway typically leads to the induction of RelA or c-Rel containing complexes, and involves the degradation of IkappaBalpha in a manner dependent on IkappaB kinase (IKK) beta and the IKK regulatory subunit NEMO
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