HCSGD entry for RGS5
1. General information
| Official gene symbol | RGS5 |
|---|---|
| Entrez ID | 8490 |
| Gene full name | regulator of G-protein signaling 5 |
| Other gene symbols | MST092 MST106 MST129 MSTP032 MSTP092 MSTP106 MSTP129 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IBA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IBA | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0008277 | Regulation of G-protein coupled receptor protein signaling pathway | TAS | biological_process |
| GO:0038032 | Termination of G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | IBA TAS | biological_process |
| GO:0043547 | Positive regulation of GTPase activity | IBA TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | IBA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4064336005 | 0.0876844193 | 0.9999902473 | 0.5615429684 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0072686220 |
| GSE13712_SHEAR | Down | -0.1761748271 |
| GSE13712_STATIC | Down | -0.1131645209 |
| GSE19018 | Down | -0.3886484172 |
| GSE19899_A1 | Up | 0.2533228379 |
| GSE19899_A2 | Up | 1.3216665213 |
| PubMed_21979375_A1 | Down | -0.4401232496 |
| PubMed_21979375_A2 | Down | -0.8683533495 |
| GSE35957 | Up | 0.6407509023 |
| GSE36640 | Up | 0.6342458243 |
| GSE54402 | Down | -0.1944607323 |
| GSE9593 | Up | 0.1345014558 |
| GSE43922 | Down | -0.6611304705 |
| GSE24585 | Up | 0.2362731378 |
| GSE37065 | Down | -0.0027625731 |
| GSE28863_A1 | Down | -0.4726895336 |
| GSE28863_A2 | Down | -0.2295875635 |
| GSE28863_A3 | Down | -0.2185797275 |
| GSE28863_A4 | Down | -0.1782599924 |
| GSE48662 | Down | -0.0234143637 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-142-3p | MIMAT0000434 | MIRT021577 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17627613 | It was found that five genes encoding ESE-3, inhibin betaA, RGS5, SSAT and DIO2 were up-regulated in senescent cells induced by RasV12, H(2)O(2) and telomere shortening, but not in quiescent or actively growing cells, suggesting that these genes serve as molecular markers for various types of cellular senescence |
| 17627613 | In contrast, RGS5, SSAT and the constitutive active form of the inhibin betaA receptor gene did not induce such senescence phenotypes when ectopically expressed |
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